KEGG for linking genomes to life and the environment

Minoru Kanehisa, Michihiro Araki, Susumu Goto, Masahiro Hattori, Mika Hirakawa, Masumi Itoh, Toshiaki Katayama, Shuichi Kawashima, Shujiro Okuda, Toshiaki Tokimatsu, Yoshihiro Yamanishi

    Research output: Contribution to journalArticle

    2977 Citations (Scopus)

    Abstract

    KEGG (http://www.genome.jp/kegg/) is a database of biological systems that integrates genomic, chemical and systemic functional information. KEGG provides a reference knowledge base for linking genomes to life through the process of PATHWAY mapping, which is to map, for example, a genomic or transcriptomic content of genes to KEGG reference pathways to infer systemic behaviors of the cell or the organism. In addition, KEGG provides a reference knowledge base for linking genomes to the environment, such as for the analysis of drug-target relationships, through the process of BRITE mapping. KEGG BRITE is an ontology database representing functional hierarchies of various biological objects, including molecules, cells, organisms, diseases and drugs, as well as relationships among them. KEGG PATHWAY is now supplemented with a new global map of metabolic pathways, which is essentially a combined map of about 120 existing pathway maps. In addition, smaller pathway modules are defined and stored in KEGG MODULE that also contains other functional units and complexes. The KEGG resource is being expanded to suit the needs for practical applications. KEGG DRUG contains all approved drugs in the US and Japan, and KEGG DISEASE is a new database linking disease genes, pathways, drugs and diagnostic markers.

    Original languageEnglish
    Pages (from-to)D480-D484
    JournalNucleic acids research
    Volume36
    Issue numberSUPPL. 1
    DOIs
    Publication statusPublished - Jan 1 2008

    Fingerprint

    Genome
    Knowledge Bases
    Databases
    Pharmaceutical Preparations
    Metabolic Networks and Pathways
    Genes
    Japan

    All Science Journal Classification (ASJC) codes

    • Genetics

    Cite this

    Kanehisa, M., Araki, M., Goto, S., Hattori, M., Hirakawa, M., Itoh, M., ... Yamanishi, Y. (2008). KEGG for linking genomes to life and the environment. Nucleic acids research, 36(SUPPL. 1), D480-D484. https://doi.org/10.1093/nar/gkm882

    KEGG for linking genomes to life and the environment. / Kanehisa, Minoru; Araki, Michihiro; Goto, Susumu; Hattori, Masahiro; Hirakawa, Mika; Itoh, Masumi; Katayama, Toshiaki; Kawashima, Shuichi; Okuda, Shujiro; Tokimatsu, Toshiaki; Yamanishi, Yoshihiro.

    In: Nucleic acids research, Vol. 36, No. SUPPL. 1, 01.01.2008, p. D480-D484.

    Research output: Contribution to journalArticle

    Kanehisa, M, Araki, M, Goto, S, Hattori, M, Hirakawa, M, Itoh, M, Katayama, T, Kawashima, S, Okuda, S, Tokimatsu, T & Yamanishi, Y 2008, 'KEGG for linking genomes to life and the environment', Nucleic acids research, vol. 36, no. SUPPL. 1, pp. D480-D484. https://doi.org/10.1093/nar/gkm882
    Kanehisa M, Araki M, Goto S, Hattori M, Hirakawa M, Itoh M et al. KEGG for linking genomes to life and the environment. Nucleic acids research. 2008 Jan 1;36(SUPPL. 1):D480-D484. https://doi.org/10.1093/nar/gkm882
    Kanehisa, Minoru ; Araki, Michihiro ; Goto, Susumu ; Hattori, Masahiro ; Hirakawa, Mika ; Itoh, Masumi ; Katayama, Toshiaki ; Kawashima, Shuichi ; Okuda, Shujiro ; Tokimatsu, Toshiaki ; Yamanishi, Yoshihiro. / KEGG for linking genomes to life and the environment. In: Nucleic acids research. 2008 ; Vol. 36, No. SUPPL. 1. pp. D480-D484.
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