Kidney-specific expression of a novel mouse organic cation transporter-like protein

Kiyoshi Mori, Yoshihiro Ogawa, Ken Ebihara, Tomohiro Aoki, Naohisa Tamura, Akira Sugawara, Takashi Kuwahara, Shoichi Ozaki, Masashi Mukoyama, Kei Tashiro, Issei Tanaka, Kazuwa Nakao

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Abstract

Using the signal sequence trap method, we have cloned a novel 12-membrane-spanning transporter-like protein, termed renal-specific transporter (RST), from the mouse kidney. RST is a 553-amino-acid protein highly homologous to recently cloned organic cation transporters, e.g. it is 30% identical to rat organic cation transporter 1 at the amino acid level. Northern blot analysis has revealed that the RST gene is expressed abundantly and specifically in the kidney. In situ hybridization analysis has shown that RST gene expression is restricted to the renal proximal tubule, where various organic cations such as endogenous catecholamines and choline or clinically used cationic drugs are known to he actively excreted.

Original languageEnglish
Pages (from-to)371-374
Number of pages4
JournalFEBS Letters
Volume417
Issue number3
DOIs
Publication statusPublished - Nov 17 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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    Mori, K., Ogawa, Y., Ebihara, K., Aoki, T., Tamura, N., Sugawara, A., Kuwahara, T., Ozaki, S., Mukoyama, M., Tashiro, K., Tanaka, I., & Nakao, K. (1997). Kidney-specific expression of a novel mouse organic cation transporter-like protein. FEBS Letters, 417(3), 371-374. https://doi.org/10.1016/S0014-5793(97)01325-2