TY - JOUR
T1 - Kidney-specific expression of a novel mouse organic cation transporter-like protein
AU - Mori, Kiyoshi
AU - Ogawa, Yoshihiro
AU - Ebihara, Ken
AU - Aoki, Tomohiro
AU - Tamura, Naohisa
AU - Sugawara, Akira
AU - Kuwahara, Takashi
AU - Ozaki, Shoichi
AU - Mukoyama, Masashi
AU - Tashiro, Kei
AU - Tanaka, Issei
AU - Nakao, Kazuwa
N1 - Funding Information:
We thank Prof. T. Honjo, Department of Medical Chemistry, Kyoto University Graduate School of Medicine for encouragement. This work was supported in part by research grants from the Japanese Ministry of Education, Science and Culture, the Japanese Ministry of Health and Welfare. The nucleotide sequence reported in this paper has been submitted to the GenBank/EMBL/DDBJ databases with the accession number AB005451.
PY - 1997/11/17
Y1 - 1997/11/17
N2 - Using the signal sequence trap method, we have cloned a novel 12-membrane-spanning transporter-like protein, termed renal-specific transporter (RST), from the mouse kidney. RST is a 553-amino-acid protein highly homologous to recently cloned organic cation transporters, e.g. it is 30% identical to rat organic cation transporter 1 at the amino acid level. Northern blot analysis has revealed that the RST gene is expressed abundantly and specifically in the kidney. In situ hybridization analysis has shown that RST gene expression is restricted to the renal proximal tubule, where various organic cations such as endogenous catecholamines and choline or clinically used cationic drugs are known to he actively excreted.
AB - Using the signal sequence trap method, we have cloned a novel 12-membrane-spanning transporter-like protein, termed renal-specific transporter (RST), from the mouse kidney. RST is a 553-amino-acid protein highly homologous to recently cloned organic cation transporters, e.g. it is 30% identical to rat organic cation transporter 1 at the amino acid level. Northern blot analysis has revealed that the RST gene is expressed abundantly and specifically in the kidney. In situ hybridization analysis has shown that RST gene expression is restricted to the renal proximal tubule, where various organic cations such as endogenous catecholamines and choline or clinically used cationic drugs are known to he actively excreted.
UR - http://www.scopus.com/inward/record.url?scp=0030772953&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030772953&partnerID=8YFLogxK
U2 - 10.1016/S0014-5793(97)01325-2
DO - 10.1016/S0014-5793(97)01325-2
M3 - Article
C2 - 9409754
AN - SCOPUS:0030772953
SN - 0014-5793
VL - 417
SP - 371
EP - 374
JO - FEBS Letters
JF - FEBS Letters
IS - 3
ER -