KIF15 Εxpression in Τumor-associated Μonocytes Ιs a prognostic biomarker in hepatocellular carcinoma

Akihiro Kitagawa, Takaaki Masuda, Junichi Takahashi, Taro Tobo, Miwa Noda, Yosuke Kuroda, Qingjiang Hu, Yuta Kouyama, Yuta Kobayashi, Shotaro Kuramitsu, Kuniaki Sato, Atsushi Fujii, Yukihiro Yoshikawa, hiroaki wakiyama, Dai Shimizu, Yusuke Tsuruda, Hidetoshi Eguchi, Yuichiro Doki, Masaki Mori, Koshi Mimori

Research output: Contribution to journalArticle

Abstract

Background/Aim: Kinesin family member 15 (KIF15) participates in the transport of macromolecules in essential cellular processes. In this study we evaluated the clinical relevance of KIF15 expression in hepatocellular carcinoma (HCC). Materials and Methods: Association between KIF15 expression and clinical outcomes in HCC patients was analyzed using three independent cohorts. Localization of KIF15 expression was assessed by immunohistochemical analysis. Co-culture experiments were performed using healthy donor peripheral blood mononuclear cells (PBMC) and HCC cell lines. Results: Immunohistochemical analysis showed that KIF15 was mainly expressed in inflammatory monocytes around cancer cells. Multivariate analysis indicated high KIF15 expression was an independent poor prognostic factor for survival. HCC cells with high expression of minichromosome maintenance protein 2 (MCM2) were located close to KIF15-expressing inflammatory monocytes. The proliferation ability of HCC cells was increased by co-culture with PBMC. Conclusion: High KIF15 expression in inflammatory monocytes in tumor tissues may serve as a prognostic marker for poor outcome in HCC.

Original languageEnglish
Pages (from-to)141-149
Number of pages9
JournalCancer Genomics and Proteomics
Volume17
Issue number2
DOIs
Publication statusPublished - Jan 1 2020

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cancer Research

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  • Cite this

    Kitagawa, A., Masuda, T., Takahashi, J., Tobo, T., Noda, M., Kuroda, Y., Hu, Q., Kouyama, Y., Kobayashi, Y., Kuramitsu, S., Sato, K., Fujii, A., Yoshikawa, Y., wakiyama, H., Shimizu, D., Tsuruda, Y., Eguchi, H., Doki, Y., Mori, M., & Mimori, K. (2020). KIF15 Εxpression in Τumor-associated Μonocytes Ιs a prognostic biomarker in hepatocellular carcinoma. Cancer Genomics and Proteomics, 17(2), 141-149. https://doi.org/10.21873/cgp.20174