Kinetic effect of cationic comb-type copolymers on DNA hybridization

Atsushi Maruyama, Longliang Wu, Naohiko Shimada, Arihiro Kano

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have been interested in the soluble interpolyelectrolyte complexes (IPEC) between DNA and the cationic comb-type copolymers, poly(L-lysine)-graft- dextran (PLL-g-Dex), consisting of a polylysine backbone and abundant hydrophilic graft chains of dextran as a model of nucleic acid-binding proteins. In this paper, we described the kinetic effect of the copolymers on the DNA hybridization. We found that the cationic copolymer at nano molar concentrations in cationic groups accelerated DNA duplex formation by two orders under physiologically relevant conditions.

Original languageEnglish
Title of host publicationMulti-functional Materials and Structures - International Conference on Multifunctional Materials and Structures
PublisherTrans Tech Publications
Pages1355-1358
Number of pages4
ISBN (Print)0878493786, 9780878493784
DOIs
Publication statusPublished - 2008
EventMulti-functional Materials and Structures - International Conference on Multifunctional Materials and Structures - Hong Kong, P.R., China
Duration: Jul 28 2008Jul 31 2008

Publication series

NameAdvanced Materials Research
Volume47-50 PART 2
ISSN (Print)1022-6680

Other

OtherMulti-functional Materials and Structures - International Conference on Multifunctional Materials and Structures
CountryChina
CityHong Kong, P.R.
Period7/28/087/31/08

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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