TY - GEN
T1 - Kinetic effect of cationic comb-type copolymers on DNA hybridization
AU - Maruyama, Atsushi
AU - Wu, Longliang
AU - Shimada, Naohiko
AU - Kano, Arihiro
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2008
Y1 - 2008
N2 - We have been interested in the soluble interpolyelectrolyte complexes (IPEC) between DNA and the cationic comb-type copolymers, poly(L-lysine)-graft- dextran (PLL-g-Dex), consisting of a polylysine backbone and abundant hydrophilic graft chains of dextran as a model of nucleic acid-binding proteins. In this paper, we described the kinetic effect of the copolymers on the DNA hybridization. We found that the cationic copolymer at nano molar concentrations in cationic groups accelerated DNA duplex formation by two orders under physiologically relevant conditions.
AB - We have been interested in the soluble interpolyelectrolyte complexes (IPEC) between DNA and the cationic comb-type copolymers, poly(L-lysine)-graft- dextran (PLL-g-Dex), consisting of a polylysine backbone and abundant hydrophilic graft chains of dextran as a model of nucleic acid-binding proteins. In this paper, we described the kinetic effect of the copolymers on the DNA hybridization. We found that the cationic copolymer at nano molar concentrations in cationic groups accelerated DNA duplex formation by two orders under physiologically relevant conditions.
UR - http://www.scopus.com/inward/record.url?scp=56349171875&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=56349171875&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/amr.47-50.1355
DO - 10.4028/www.scientific.net/amr.47-50.1355
M3 - Conference contribution
AN - SCOPUS:56349171875
SN - 0878493786
SN - 9780878493784
T3 - Advanced Materials Research
SP - 1355
EP - 1358
BT - Multi-functional Materials and Structures - International Conference on Multifunctional Materials and Structures
PB - Trans Tech Publications
T2 - Multi-functional Materials and Structures - International Conference on Multifunctional Materials and Structures
Y2 - 28 July 2008 through 31 July 2008
ER -