Kinetic resolution of axially chiral 2,2′-dihydroxy-1,1′- biaryls by palladium-catalyzed alcoholysis

Hiroshi Aoyama, Makoto Tokunaga, Junya Kiyosu, Tetsuo Iwasawa, Yasushi Obora, Yasushi Tsuji

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Palladium-diamine complexes catalyzed kinetic resolution of axially chiral 2,2′-dihydroxy-1,1′-biaryls by alcoholysis of vinyl ethers. The reaction proceeded with high selectivity for various kinds of biaryls. This process is applicable to not only binaphthols but also biphenols, which have been considered to be difficult for the enantioselective synthesis by known catalytic methods.

Original languageEnglish
Pages (from-to)10474-10475
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number30
DOIs
Publication statusPublished - Aug 3 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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