Kinetic resolution of axially chiral 2,2′-dihydroxy-1,1′- biaryls by palladium-catalyzed alcoholysis

Hiroshi Aoyama, Makoto Tokunaga, Junya Kiyosu, Tetsuo Iwasawa, Yasushi Obora, Yasushi Tsuji

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Palladium-diamine complexes catalyzed kinetic resolution of axially chiral 2,2′-dihydroxy-1,1′-biaryls by alcoholysis of vinyl ethers. The reaction proceeded with high selectivity for various kinds of biaryls. This process is applicable to not only binaphthols but also biphenols, which have been considered to be difficult for the enantioselective synthesis by known catalytic methods.

Original languageEnglish
Pages (from-to)10474-10475
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number30
DOIs
Publication statusPublished - Aug 3 2005
Externally publishedYes

Fingerprint

Diamines
Palladium
Ethers
Kinetics
vinyl ether

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Kinetic resolution of axially chiral 2,2′-dihydroxy-1,1′- biaryls by palladium-catalyzed alcoholysis. / Aoyama, Hiroshi; Tokunaga, Makoto; Kiyosu, Junya; Iwasawa, Tetsuo; Obora, Yasushi; Tsuji, Yasushi.

In: Journal of the American Chemical Society, Vol. 127, No. 30, 03.08.2005, p. 10474-10475.

Research output: Contribution to journalArticle

Aoyama, Hiroshi ; Tokunaga, Makoto ; Kiyosu, Junya ; Iwasawa, Tetsuo ; Obora, Yasushi ; Tsuji, Yasushi. / Kinetic resolution of axially chiral 2,2′-dihydroxy-1,1′- biaryls by palladium-catalyzed alcoholysis. In: Journal of the American Chemical Society. 2005 ; Vol. 127, No. 30. pp. 10474-10475.
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