Kinetics of circulating haematopoietic progenitors during chemotherapy‐induced mobilization with or without granulocyte colony‐stimulating factor

Kai‐Yan ‐Y Liu, Koichi Akashi, Mine Harada, Yasushi Takamatsu, Yoshiyuki Niho

Research output: Contribution to journalArticle

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Abstract

Summary. Kinetics of circulating haematopoietic progenitors was analysed during chemotherapy‐ or chemotherapy plus granulocyte colony‐stimulating factor (G‐CSF)‐induced mobilization of peripheral blood stem cells. Circulating progenitors including colony‐forming unit granulocyte/macrophage (CFU‐GM), burst forming‐unit erythroid (BFU‐E) and multilineage colony forming unit (CFU‐Mix) were studied serially on alternate days during a recovery phase from chemotherapy for consolidation of complete remission. In 18 patients with acute leukaemia, 27 courses of consolidation chemotherapy were performed with a combination of an intermediate‐dose cytosine arabinoside with etoposide (Ara‐C/Etop) or mitoxantron (Ara‐C/Mit). G‐CSF (5 μg/kg) was administered during the recovery phase in 6/14 courses with Ara‐C/Etop and in 4/13 courses with Ara‐C/Mit. G‐CSF induced a significant and synchronized increase of circulating CFU‐GM, BFU‐E and CFU‐Mix by more than 4‐fold at their peaks. The peak of CFU‐GM was significantly correlated with that of both BFU‐E and CFU‐Mix, irrespective of additional G‐CSF mobilization. G‐CSF also produced a significant increase of monocytes in a synchronized fashion with an increase of circulating CFU‐GM. Interestingly, peripheral blood monocytes spontaneously produced high concentrations of IL‐6; a significant correlation was observed between absolute monocyte counts and plasma levels of IL‐6 or peak levels of CFU‐GM. These observations indicate that the addition of G‐CSF to chemotherapy‐induced mobilization can facilitate further expansion of a blood progenitor pool during the haematopoietic recovery, probably through the stimulation of monocytes to proliferate and to induce their monokine production such as IL‐6. The data also suggest that absolute monocyte counts may be a useful indicator to predict the peak of circulating progenitors for collecting autologous blood stem cells.

Original languageEnglish
Pages (from-to)31-38
Number of pages8
JournalBritish Journal of Haematology
Volume84
Issue number1
DOIs
Publication statusPublished - Jan 1 1993
Externally publishedYes

Fingerprint

Granulocytes
Monocytes
Macrophages
Consolidation Chemotherapy
Interleukin-6
Monokines
Drug Therapy
Erythroid Precursor Cells
Cytarabine
Etoposide
Blood Cells
Leukemia
Stem Cells

All Science Journal Classification (ASJC) codes

  • Hematology

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Kinetics of circulating haematopoietic progenitors during chemotherapy‐induced mobilization with or without granulocyte colony‐stimulating factor. / Liu, Kai‐Yan ‐Y; Akashi, Koichi; Harada, Mine; Takamatsu, Yasushi; Niho, Yoshiyuki.

In: British Journal of Haematology, Vol. 84, No. 1, 01.01.1993, p. 31-38.

Research output: Contribution to journalArticle

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