Abstract
We examined the kinetics of intestinal intraepithelial lymphocytes (IEL) and the incidence of apoptosis at villus or crypt sites during the development of non‐irradiated acute graft‐versus‐host disease (GVHD). The first IEL to increase were host‐origin on day 3 and the donor‐derived IEL appeared first on day 12 after GVHD induction. Unique CD3+CD4+CD8α/α+ IEL were significantly increased on day 6 and an appreciable number of IEL bearing T cell receptor Vβ capable of recognizing self‐superantigen were detected on day 9. The sudden appearance of apoptosis and reduction of mitotic activity occurred on day 12, accompanied by a dramatic decrease of CD3+CD4−CD8α/α+ IEL of host origin. CD8α/α+ IEL of host origin, which expand and then decrease by apoptosis at the early stage of acute GVHD, may be associated with pathogenesis of the enteropathy occurring during acute GVHD.
| Original language | English |
|---|---|
| Pages (from-to) | 709-715 |
| Number of pages | 7 |
| Journal | European Journal of Immunology |
| Volume | 24 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jan 1 1994 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
Cite this
Kinetics of intestinal intraepithelial lymphocytes during acute graft‐versus‐host disease in mice. / Tsuzuki, Toyonori; Yoshikai, Yasunobu; Ito, Masafumi; Mori, Naoyoshi; Ohbayashi, Masaharu; Asai, Junpei.
In: European Journal of Immunology, Vol. 24, No. 3, 01.01.1994, p. 709-715.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Kinetics of intestinal intraepithelial lymphocytes during acute graft‐versus‐host disease in mice
AU - Tsuzuki, Toyonori
AU - Yoshikai, Yasunobu
AU - Ito, Masafumi
AU - Mori, Naoyoshi
AU - Ohbayashi, Masaharu
AU - Asai, Junpei
PY - 1994/1/1
Y1 - 1994/1/1
N2 - We examined the kinetics of intestinal intraepithelial lymphocytes (IEL) and the incidence of apoptosis at villus or crypt sites during the development of non‐irradiated acute graft‐versus‐host disease (GVHD). The first IEL to increase were host‐origin on day 3 and the donor‐derived IEL appeared first on day 12 after GVHD induction. Unique CD3+CD4+CD8α/α+ IEL were significantly increased on day 6 and an appreciable number of IEL bearing T cell receptor Vβ capable of recognizing self‐superantigen were detected on day 9. The sudden appearance of apoptosis and reduction of mitotic activity occurred on day 12, accompanied by a dramatic decrease of CD3+CD4−CD8α/α+ IEL of host origin. CD8α/α+ IEL of host origin, which expand and then decrease by apoptosis at the early stage of acute GVHD, may be associated with pathogenesis of the enteropathy occurring during acute GVHD.
AB - We examined the kinetics of intestinal intraepithelial lymphocytes (IEL) and the incidence of apoptosis at villus or crypt sites during the development of non‐irradiated acute graft‐versus‐host disease (GVHD). The first IEL to increase were host‐origin on day 3 and the donor‐derived IEL appeared first on day 12 after GVHD induction. Unique CD3+CD4+CD8α/α+ IEL were significantly increased on day 6 and an appreciable number of IEL bearing T cell receptor Vβ capable of recognizing self‐superantigen were detected on day 9. The sudden appearance of apoptosis and reduction of mitotic activity occurred on day 12, accompanied by a dramatic decrease of CD3+CD4−CD8α/α+ IEL of host origin. CD8α/α+ IEL of host origin, which expand and then decrease by apoptosis at the early stage of acute GVHD, may be associated with pathogenesis of the enteropathy occurring during acute GVHD.
UR - http://www.scopus.com/inward/record.url?scp=0028294338&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028294338&partnerID=8YFLogxK
U2 - 10.1002/eji.1830240333
DO - 10.1002/eji.1830240333
M3 - Article
C2 - 7907297
AN - SCOPUS:0028294338
VL - 24
SP - 709
EP - 715
JO - European Journal of Immunology
JF - European Journal of Immunology
SN - 0014-2980
IS - 3
ER -