Kinetics of thermal [1,7A]-sigmatropic shift of hexafluoro vitamin D3 and vitamin D3 derivatives. Evaluation of conformations of the A ring affected by 1-OH and 3-OH groups

Junetsu Igarashi, Masahiko Ikeda, Makoto Sunagawa

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The quantitative evaluation of the [1,7a]-sigmatropic rearrangement of vitamin D3 and its analogs affected by the conformations of the A ring using the 1H-NMR method was described. Although the side chain of the D ring had no effect on the hydrogen migration, the rearrangement was influenced by the hydroxy groups of the A ring.

Original languageEnglish
Pages (from-to)1431-1436
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number13
DOIs
Publication statusPublished - Jul 9 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Kinetics of thermal [1,7A]-sigmatropic shift of hexafluoro vitamin D<sub>3</sub> and vitamin D<sub>3</sub> derivatives. Evaluation of conformations of the A ring affected by 1-OH and 3-OH groups'. Together they form a unique fingerprint.

Cite this