TY - CHAP
T1 - Knockout Mouse Models Provide Insight into the Biological Functions of CRL1 Components
AU - Nakagawa, Tadashi
AU - Nakayama, Keiko
AU - Nakayama, Keiichi I.
N1 - Funding Information:
We thank H. Inuzuka and W. Wei for the discussion. This study was funded in part by KAKENHI grants (18H05215) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan.
Publisher Copyright:
© Springer Nature Singapore Pte Ltd. 2020.
PY - 2020
Y1 - 2020
N2 - The CRL1 complex, also known as the SCF complex, is a ubiquitin ligase that in mammals consists of an adaptor protein (SKP1), a scaffold protein (CUL1), a RING finger protein (RBX1, also known as ROC1), and one of about 70 F-box proteins. Given that the F-box proteins determine the substrate specificity of the CRL1 complex, the variety of these proteins allows the generation of a large number of ubiquitin ligases that promote the degradation or regulate the function of many substrate proteins and thereby control numerous key cellular processes. The physiological and pathological functions of these many CRL1 ubiquitin ligases have been studied by the generation and characterization of knockout mouse models that lack specific CRL1 components. In this chapter, we provide a comprehensive overview of these mouse models and discuss the role of each CRL1 component in mouse physiology and pathology.
AB - The CRL1 complex, also known as the SCF complex, is a ubiquitin ligase that in mammals consists of an adaptor protein (SKP1), a scaffold protein (CUL1), a RING finger protein (RBX1, also known as ROC1), and one of about 70 F-box proteins. Given that the F-box proteins determine the substrate specificity of the CRL1 complex, the variety of these proteins allows the generation of a large number of ubiquitin ligases that promote the degradation or regulate the function of many substrate proteins and thereby control numerous key cellular processes. The physiological and pathological functions of these many CRL1 ubiquitin ligases have been studied by the generation and characterization of knockout mouse models that lack specific CRL1 components. In this chapter, we provide a comprehensive overview of these mouse models and discuss the role of each CRL1 component in mouse physiology and pathology.
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U2 - 10.1007/978-981-15-1025-0_10
DO - 10.1007/978-981-15-1025-0_10
M3 - Chapter
C2 - 31898227
AN - SCOPUS:85077471459
T3 - Advances in Experimental Medicine and Biology
SP - 147
EP - 171
BT - Advances in Experimental Medicine and Biology
PB - Springer
ER -