Korean, Japanese, and Chinese populations featured similar genes encoding drug-metabolizing enzymes and transporters: A DMET Plus microarray assessment

Sojeong Yi, Hyungmi An, Howard Lee, Sangin Lee, Ichiro Ieiri, Youngjo Lee, Joo Youn Cho, Takeshi Hirota, Masato Fukae, Kenji Yoshida, Shinichiro Nagatsuka, Miyuki Kimura, Shin Irie, Yuichi Sugiyama, Dong Wan Shin, Kyoung Soo Lim, Jae Yong Chung, Kyung Sang Yu, In Jin Jang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Results: On microarray analysis, 1071 of 1936 variants (>50% of markers) were found to be monomorphic. In a large number of genetic variants, the fixation index and Pearson's correlation coefficient of minor allele frequencies were less than 0.034 and greater than 0.95, respectively, among the three ethnic groups. PCA identified 47 genetic variants with multiple testing, but was unable to discriminate ethnic groups by the first three components. Multinomial least absolute shrinkage and selection operator analysis identified 269 genetic variants that showed different frequencies among the three ethnic groups. However, none of those variants distinguished between the three ethnic groups during subsequent PCA.

Conclusion: Korean, Japanese, and Chinese populations are not pharmacogenetically distant from one another, at least with regard to drug disposition, metabolism, and elimination.

Background: Interethnic differences in genetic polymorphism in genes encoding drug-metabolizing enzymes and transporters are one of the major factors that cause ethnic differences in drug response. This study aimed to investigate genetic polymorphisms in genes involved in drug metabolism, transport, and excretion among Korean, Japanese, and Chinese populations, the three major East Asian ethnic groups.

Methods: The frequencies of 1936 variants representing 225 genes encoding drug-metabolizing enzymes and transporters were determined from 786 healthy participants (448 Korean, 208 Japanese, and 130 Chinese) using the Affymetrix Drug-Metabolizing Enzymes and Transporters Plus microarray. To compare allele or genotype frequencies in the high-dimensional data among the three East Asian ethnic groups, multiple testing, principal component analysis (PCA), and regularized multinomial logit model through least absolute shrinkage and selection operator were used.

Original languageEnglish
Pages (from-to)477-485
Number of pages9
JournalPharmacogenetics and Genomics
Volume24
Issue number10
DOIs
Publication statusPublished - Oct 10 2014

Fingerprint

Ethnic Groups
Enzymes
Principal Component Analysis
Pharmaceutical Preparations
Population
Genes
Genetic Polymorphisms
Microarray Analysis
Gene Frequency
Healthy Volunteers
Logistic Models
Alleles
Genotype

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Korean, Japanese, and Chinese populations featured similar genes encoding drug-metabolizing enzymes and transporters : A DMET Plus microarray assessment. / Yi, Sojeong; An, Hyungmi; Lee, Howard; Lee, Sangin; Ieiri, Ichiro; Lee, Youngjo; Cho, Joo Youn; Hirota, Takeshi; Fukae, Masato; Yoshida, Kenji; Nagatsuka, Shinichiro; Kimura, Miyuki; Irie, Shin; Sugiyama, Yuichi; Shin, Dong Wan; Lim, Kyoung Soo; Chung, Jae Yong; Yu, Kyung Sang; Jang, In Jin.

In: Pharmacogenetics and Genomics, Vol. 24, No. 10, 10.10.2014, p. 477-485.

Research output: Contribution to journalArticle

Yi, S, An, H, Lee, H, Lee, S, Ieiri, I, Lee, Y, Cho, JY, Hirota, T, Fukae, M, Yoshida, K, Nagatsuka, S, Kimura, M, Irie, S, Sugiyama, Y, Shin, DW, Lim, KS, Chung, JY, Yu, KS & Jang, IJ 2014, 'Korean, Japanese, and Chinese populations featured similar genes encoding drug-metabolizing enzymes and transporters: A DMET Plus microarray assessment', Pharmacogenetics and Genomics, vol. 24, no. 10, pp. 477-485. https://doi.org/10.1097/FPC.0000000000000075
Yi, Sojeong ; An, Hyungmi ; Lee, Howard ; Lee, Sangin ; Ieiri, Ichiro ; Lee, Youngjo ; Cho, Joo Youn ; Hirota, Takeshi ; Fukae, Masato ; Yoshida, Kenji ; Nagatsuka, Shinichiro ; Kimura, Miyuki ; Irie, Shin ; Sugiyama, Yuichi ; Shin, Dong Wan ; Lim, Kyoung Soo ; Chung, Jae Yong ; Yu, Kyung Sang ; Jang, In Jin. / Korean, Japanese, and Chinese populations featured similar genes encoding drug-metabolizing enzymes and transporters : A DMET Plus microarray assessment. In: Pharmacogenetics and Genomics. 2014 ; Vol. 24, No. 10. pp. 477-485.
@article{640b03576ea0413b8c6b22f12eae5457,
title = "Korean, Japanese, and Chinese populations featured similar genes encoding drug-metabolizing enzymes and transporters: A DMET Plus microarray assessment",
abstract = "Results: On microarray analysis, 1071 of 1936 variants (>50{\%} of markers) were found to be monomorphic. In a large number of genetic variants, the fixation index and Pearson's correlation coefficient of minor allele frequencies were less than 0.034 and greater than 0.95, respectively, among the three ethnic groups. PCA identified 47 genetic variants with multiple testing, but was unable to discriminate ethnic groups by the first three components. Multinomial least absolute shrinkage and selection operator analysis identified 269 genetic variants that showed different frequencies among the three ethnic groups. However, none of those variants distinguished between the three ethnic groups during subsequent PCA.Conclusion: Korean, Japanese, and Chinese populations are not pharmacogenetically distant from one another, at least with regard to drug disposition, metabolism, and elimination.Background: Interethnic differences in genetic polymorphism in genes encoding drug-metabolizing enzymes and transporters are one of the major factors that cause ethnic differences in drug response. This study aimed to investigate genetic polymorphisms in genes involved in drug metabolism, transport, and excretion among Korean, Japanese, and Chinese populations, the three major East Asian ethnic groups.Methods: The frequencies of 1936 variants representing 225 genes encoding drug-metabolizing enzymes and transporters were determined from 786 healthy participants (448 Korean, 208 Japanese, and 130 Chinese) using the Affymetrix Drug-Metabolizing Enzymes and Transporters Plus microarray. To compare allele or genotype frequencies in the high-dimensional data among the three East Asian ethnic groups, multiple testing, principal component analysis (PCA), and regularized multinomial logit model through least absolute shrinkage and selection operator were used.",
author = "Sojeong Yi and Hyungmi An and Howard Lee and Sangin Lee and Ichiro Ieiri and Youngjo Lee and Cho, {Joo Youn} and Takeshi Hirota and Masato Fukae and Kenji Yoshida and Shinichiro Nagatsuka and Miyuki Kimura and Shin Irie and Yuichi Sugiyama and Shin, {Dong Wan} and Lim, {Kyoung Soo} and Chung, {Jae Yong} and Yu, {Kyung Sang} and Jang, {In Jin}",
year = "2014",
month = "10",
day = "10",
doi = "10.1097/FPC.0000000000000075",
language = "English",
volume = "24",
pages = "477--485",
journal = "Pharmacogenetics and Genomics",
issn = "1744-6872",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - Korean, Japanese, and Chinese populations featured similar genes encoding drug-metabolizing enzymes and transporters

T2 - A DMET Plus microarray assessment

AU - Yi, Sojeong

AU - An, Hyungmi

AU - Lee, Howard

AU - Lee, Sangin

AU - Ieiri, Ichiro

AU - Lee, Youngjo

AU - Cho, Joo Youn

AU - Hirota, Takeshi

AU - Fukae, Masato

AU - Yoshida, Kenji

AU - Nagatsuka, Shinichiro

AU - Kimura, Miyuki

AU - Irie, Shin

AU - Sugiyama, Yuichi

AU - Shin, Dong Wan

AU - Lim, Kyoung Soo

AU - Chung, Jae Yong

AU - Yu, Kyung Sang

AU - Jang, In Jin

PY - 2014/10/10

Y1 - 2014/10/10

N2 - Results: On microarray analysis, 1071 of 1936 variants (>50% of markers) were found to be monomorphic. In a large number of genetic variants, the fixation index and Pearson's correlation coefficient of minor allele frequencies were less than 0.034 and greater than 0.95, respectively, among the three ethnic groups. PCA identified 47 genetic variants with multiple testing, but was unable to discriminate ethnic groups by the first three components. Multinomial least absolute shrinkage and selection operator analysis identified 269 genetic variants that showed different frequencies among the three ethnic groups. However, none of those variants distinguished between the three ethnic groups during subsequent PCA.Conclusion: Korean, Japanese, and Chinese populations are not pharmacogenetically distant from one another, at least with regard to drug disposition, metabolism, and elimination.Background: Interethnic differences in genetic polymorphism in genes encoding drug-metabolizing enzymes and transporters are one of the major factors that cause ethnic differences in drug response. This study aimed to investigate genetic polymorphisms in genes involved in drug metabolism, transport, and excretion among Korean, Japanese, and Chinese populations, the three major East Asian ethnic groups.Methods: The frequencies of 1936 variants representing 225 genes encoding drug-metabolizing enzymes and transporters were determined from 786 healthy participants (448 Korean, 208 Japanese, and 130 Chinese) using the Affymetrix Drug-Metabolizing Enzymes and Transporters Plus microarray. To compare allele or genotype frequencies in the high-dimensional data among the three East Asian ethnic groups, multiple testing, principal component analysis (PCA), and regularized multinomial logit model through least absolute shrinkage and selection operator were used.

AB - Results: On microarray analysis, 1071 of 1936 variants (>50% of markers) were found to be monomorphic. In a large number of genetic variants, the fixation index and Pearson's correlation coefficient of minor allele frequencies were less than 0.034 and greater than 0.95, respectively, among the three ethnic groups. PCA identified 47 genetic variants with multiple testing, but was unable to discriminate ethnic groups by the first three components. Multinomial least absolute shrinkage and selection operator analysis identified 269 genetic variants that showed different frequencies among the three ethnic groups. However, none of those variants distinguished between the three ethnic groups during subsequent PCA.Conclusion: Korean, Japanese, and Chinese populations are not pharmacogenetically distant from one another, at least with regard to drug disposition, metabolism, and elimination.Background: Interethnic differences in genetic polymorphism in genes encoding drug-metabolizing enzymes and transporters are one of the major factors that cause ethnic differences in drug response. This study aimed to investigate genetic polymorphisms in genes involved in drug metabolism, transport, and excretion among Korean, Japanese, and Chinese populations, the three major East Asian ethnic groups.Methods: The frequencies of 1936 variants representing 225 genes encoding drug-metabolizing enzymes and transporters were determined from 786 healthy participants (448 Korean, 208 Japanese, and 130 Chinese) using the Affymetrix Drug-Metabolizing Enzymes and Transporters Plus microarray. To compare allele or genotype frequencies in the high-dimensional data among the three East Asian ethnic groups, multiple testing, principal component analysis (PCA), and regularized multinomial logit model through least absolute shrinkage and selection operator were used.

UR - http://www.scopus.com/inward/record.url?scp=84916196118&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84916196118&partnerID=8YFLogxK

U2 - 10.1097/FPC.0000000000000075

DO - 10.1097/FPC.0000000000000075

M3 - Article

C2 - 25029633

AN - SCOPUS:84916196118

VL - 24

SP - 477

EP - 485

JO - Pharmacogenetics and Genomics

JF - Pharmacogenetics and Genomics

SN - 1744-6872

IS - 10

ER -