K‐ras activation in colorectal tumors from patients with familial polyposis coli

Masayuki Sasaki, Kenji Sugio, Takehiko Sasazuki

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

K‐ras gene mutation in colorectal tumors from patients with familial polyposis coli were investigated using oligonucleotide probes specific for a mutation at codon 12, 13, or 61 of the K‐ras gene. The authors examined 22 colorectal carcinomas and 51 colorectal adenomas from 41 familial polyposis coli patients and observed mutations at codons 12 and 13 in eight of 22 colorectal carcinomas (36%) and six of 51 colorectal adenomas (12%). Thus, the frequency and sites of K‐ras gene mutation in colorectal carcinoma from familial polyposis coli patients are similar to those in cases of sporadic colorectal carcinoma and may not be the first genetic event linked to the tumorigenesis.

Original languageEnglish
Pages (from-to)2576-2579
Number of pages4
JournalCancer
Volume65
Issue number11
DOIs
Publication statusPublished - Jan 1 1990

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Adenomatous Polyposis Coli
Colorectal Neoplasms
Mutation
Codon
Adenoma
Genes
Oligonucleotide Probes
Carcinogenesis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

K‐ras activation in colorectal tumors from patients with familial polyposis coli. / Sasaki, Masayuki; Sugio, Kenji; Sasazuki, Takehiko.

In: Cancer, Vol. 65, No. 11, 01.01.1990, p. 2576-2579.

Research output: Contribution to journalArticle

Sasaki, Masayuki ; Sugio, Kenji ; Sasazuki, Takehiko. / K‐ras activation in colorectal tumors from patients with familial polyposis coli. In: Cancer. 1990 ; Vol. 65, No. 11. pp. 2576-2579.
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