L-myc restriction fragment length polymorphism in Japanese patients with esophageal cancer

Kenji Shibuta, Hiroshi Inoue, Koichi Sato, Ayumi Matsuyama, Hiroaki Ueo, Youichi Tanaka, Kenichi Mafune, Graham F. Barnard, Masaki Mori

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

L-myc polymorphism is a representative genetic trait related to an individual's susceptibility to several cancers. However, there have been no reports concerning the association between esophageal cancer and L-myc polymorphism. To analyze the distribution of polymorphism in Japanese patients with esophageal cancer, a molecular genotyping method using a polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) was used. Based on an analysis of 65 Japanese patients with esophageal cancer and 107 healthy control subjects, a significant difference was observed in either the distribution of genotypes (P = 0.012) or of allele frequencies between the two groups (P = 0.004). The relative risk of esophageal cancer for genotypes including the shorter allele was 2.9 compared to the longer allele homozygote. Furthermore, the patients with S-allele had a tendency for poor prognosis among those with three genotypes. A significant difference between the distribution of genotypes and the incidence of lymph node metastasis was found based on the clinicopathological features of the cancers. These results suggest that L-myc polymorphism may be implicated as a genetic trait affecting an individual's susceptibility to esophageal cancer, at least among Japanese patients.

Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalJapanese Journal of Cancer Research
Volume91
Issue number2
DOIs
Publication statusPublished - Feb 2000

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'L-myc restriction fragment length polymorphism in Japanese patients with esophageal cancer'. Together they form a unique fingerprint.

Cite this