L-Serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neurons

Shigeki Furuya, Toshihide Tabata, Junya Mitoma, Keiko Yamada, Miwako Yamasaki, Asami Makino, Toshifumi Yamamoto, Masahiko Watanabe, Masanobu Kano, Yoshio Hirabayashi

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

Glial cells support the survival and development of central neurons through the supply of trophic factors. Here we demonstrate that L-serine (L-Ser) and glycine (Gly) also are glia-derived trophic factors. These amino acids are released by astroglial cells and promote the survival, dendritogenesis, and electrophysiological development of cultured cerebellar Purkinje neurons. Although L-Ser and Gly are generally classified as nonessential amino acids, 3-phosphoglycerate dehydrogenase (3PGDH), a key enzyme for their biosynthesis, is not expressed in Purkinje neurons. By contrast, the Bergman glia, a native astroglia in the cerebellar cortex, highly expresses 3PGDH. These data suggest that L-Ser and Gly mediate the trophic actions of glial cells on Purkinje neurons.

Original languageEnglish
Pages (from-to)11528-11533
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume97
Issue number21
DOIs
Publication statusPublished - Oct 10 2000
Externally publishedYes

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Purkinje Cells
Neuroglia
Astrocytes
Glycine
Serine
Phosphoglycerate Dehydrogenase
Cell Survival
Amino Acids
Cerebellar Cortex
Neurons
Enzymes
serine containing aminolipid

All Science Journal Classification (ASJC) codes

  • General

Cite this

L-Serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neurons. / Furuya, Shigeki; Tabata, Toshihide; Mitoma, Junya; Yamada, Keiko; Yamasaki, Miwako; Makino, Asami; Yamamoto, Toshifumi; Watanabe, Masahiko; Kano, Masanobu; Hirabayashi, Yoshio.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 21, 10.10.2000, p. 11528-11533.

Research output: Contribution to journalArticle

Furuya, S, Tabata, T, Mitoma, J, Yamada, K, Yamasaki, M, Makino, A, Yamamoto, T, Watanabe, M, Kano, M & Hirabayashi, Y 2000, 'L-Serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neurons', Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 21, pp. 11528-11533. https://doi.org/10.1073/pnas.200364497
Furuya, Shigeki ; Tabata, Toshihide ; Mitoma, Junya ; Yamada, Keiko ; Yamasaki, Miwako ; Makino, Asami ; Yamamoto, Toshifumi ; Watanabe, Masahiko ; Kano, Masanobu ; Hirabayashi, Yoshio. / L-Serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neurons. In: Proceedings of the National Academy of Sciences of the United States of America. 2000 ; Vol. 97, No. 21. pp. 11528-11533.
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AU - Furuya, Shigeki

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AU - Yamasaki, Miwako

AU - Makino, Asami

AU - Yamamoto, Toshifumi

AU - Watanabe, Masahiko

AU - Kano, Masanobu

AU - Hirabayashi, Yoshio

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