Label-free DNA detection platform based on atomic force microscopy visualisation: Characterising the molecular-recognition-triggered conformational changes of an immobilised receptor oligonucleotide probe

Koji Nakano, Hirokazu Yamanouchi, Hisao Yoshinaga, Nobuaki Soh, Toshihiko Imato

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Using atomic microscopy imaging, probe DNA sequence self-assemblies developed on Si(100) substrates undergo a conformational transition from an extended stem-loop structure to a double helix; such assemblies readily report on DNA molecular recognition events and should be suitable as a label-free, DNA hybridisation assay platform.

Original languageEnglish
Pages (from-to)5683-5685
Number of pages3
JournalChemical Communications
Volume46
Issue number31
DOIs
Publication statusPublished - Aug 21 2010

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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