Label-free DNA detection platform based on atomic force microscopy visualisation: Characterising the molecular-recognition-triggered conformational changes of an immobilised receptor oligonucleotide probe

Koji Nakano, Hirokazu Yamanouchi, Hisao Yoshinaga, Nobuaki Soh, Toshihiko Imato

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Using atomic microscopy imaging, probe DNA sequence self-assemblies developed on Si(100) substrates undergo a conformational transition from an extended stem-loop structure to a double helix; such assemblies readily report on DNA molecular recognition events and should be suitable as a label-free, DNA hybridisation assay platform.

    Original languageEnglish
    Pages (from-to)5683-5685
    Number of pages3
    JournalChemical Communications
    Volume46
    Issue number31
    DOIs
    Publication statusPublished - Aug 21 2010

    All Science Journal Classification (ASJC) codes

    • Catalysis
    • Electronic, Optical and Magnetic Materials
    • Ceramics and Composites
    • Chemistry(all)
    • Surfaces, Coatings and Films
    • Metals and Alloys
    • Materials Chemistry

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