Lack of association between the IL13 variant Arg110Gln and susceptibility to cedar pollinosis in a Japanese population

Lei Cheng, Tomomitsu Hirota, Tadao Enomoto, Mayumi Tamari, Mitsuteru Akahoshi, Akira Matsuda, Makiko Shimizu, Naomi Takahashi, Keisuke Enomoto, Akiko Yamasaki, Xiao Quan Mao, Julian M. Hopkin, Taro Shirakawa

Research output: Contribution to journalArticle

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Abstract

Background: Interleukin (IL)-13 has come to be appreciated as a molecule critically involved in allergic inflammatory responses. Recent studies revealed that a common variant in the coding region of the IL13 gene, Arg110Gln, has been implicated in the development of asthma and atopy. Methods: To assess whether the IL13 variant Arg110Gln is associated with cedar pollinosis, one of the most common atopic diseases in the Japanese population, we examined the Arg110Gln variant using PCR-RFLP to compare the genotype and allele frequencies between 95 patients with cedar pollinosis and 95 healthy control subjects. Relationships between the Arg110Gln variant and the pollinosis-related traits, e.g. rhinitis severity, eosinophil counts in nasal secretion and serum total and allergen-specific IgE levels, were also investigated. Results: The frequencies of the minor allele Gln110 were 25.8% in patients with cedar pollinosis and 30.9% in healthy control subjects (p > 0.05). There was also no significant difference in the genotype frequencies between cases and controls (p > 0.05). In addition, we found no significant association of the Arg110Gln variant with any of the pollinosis-related phenotypes (p > 0.05). Conclusions: Our data suggest lack of evidence for identifying the variant Arg110Gln at the IL13 locus as a genetic risk factor involved in the development of Japanese cedar pollinosis.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalInternational Archives of Allergy and Immunology
Volume139
Issue number1
DOIs
Publication statusPublished - Dec 1 2005
Externally publishedYes

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Seasonal Allergic Rhinitis
Interleukin-13
Population
Gene Frequency
Healthy Volunteers
Genotype
Cryptomeria
Rhinitis
Nose
Eosinophils
Restriction Fragment Length Polymorphisms
Allergens
Immunoglobulin E
Asthma
Phenotype
Polymerase Chain Reaction
Serum
Genes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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Lack of association between the IL13 variant Arg110Gln and susceptibility to cedar pollinosis in a Japanese population. / Cheng, Lei; Hirota, Tomomitsu; Enomoto, Tadao; Tamari, Mayumi; Akahoshi, Mitsuteru; Matsuda, Akira; Shimizu, Makiko; Takahashi, Naomi; Enomoto, Keisuke; Yamasaki, Akiko; Mao, Xiao Quan; Hopkin, Julian M.; Shirakawa, Taro.

In: International Archives of Allergy and Immunology, Vol. 139, No. 1, 01.12.2005, p. 25-30.

Research output: Contribution to journalArticle

Cheng, L, Hirota, T, Enomoto, T, Tamari, M, Akahoshi, M, Matsuda, A, Shimizu, M, Takahashi, N, Enomoto, K, Yamasaki, A, Mao, XQ, Hopkin, JM & Shirakawa, T 2005, 'Lack of association between the IL13 variant Arg110Gln and susceptibility to cedar pollinosis in a Japanese population', International Archives of Allergy and Immunology, vol. 139, no. 1, pp. 25-30. https://doi.org/10.1159/000089519
Cheng, Lei ; Hirota, Tomomitsu ; Enomoto, Tadao ; Tamari, Mayumi ; Akahoshi, Mitsuteru ; Matsuda, Akira ; Shimizu, Makiko ; Takahashi, Naomi ; Enomoto, Keisuke ; Yamasaki, Akiko ; Mao, Xiao Quan ; Hopkin, Julian M. ; Shirakawa, Taro. / Lack of association between the IL13 variant Arg110Gln and susceptibility to cedar pollinosis in a Japanese population. In: International Archives of Allergy and Immunology. 2005 ; Vol. 139, No. 1. pp. 25-30.
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AU - Tamari, Mayumi

AU - Akahoshi, Mitsuteru

AU - Matsuda, Akira

AU - Shimizu, Makiko

AU - Takahashi, Naomi

AU - Enomoto, Keisuke

AU - Yamasaki, Akiko

AU - Mao, Xiao Quan

AU - Hopkin, Julian M.

AU - Shirakawa, Taro

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