TY - JOUR
T1 - Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese
AU - Takahashi, M.
AU - Hashimoto, H.
AU - Akizuki, M.
AU - Sasazuki, T.
AU - Nishikimi, N.
AU - Ouchi, H.
AU - Kobayashi, Y.
AU - Numano, F.
AU - Kimura, A.
PY - 2001
Y1 - 2001
N2 - A polymorphism in high-affinity receptor of TNF (TNFR2) gene, Met196Arg, was reported to be associated with systemic lupus erythematosus (SLE) in Japanese, whereas the association could not be found in Europeans at all and this represents an apparent discrepancy. The association, then, should be tested in other populations to clarify the possible involvement, if any, of the TNFR2 polymorphism in SLE or other related autoimmune diseases. The purposes of this study were to examine the TNFR2 polymorphism in Japanese patients with SLE and to investigate its association with other autoimmune diseases accompanied by vasculitis, mixed connective tissue disease, Buerger's disease, and Takayasu's arteritis. We found no association at all between the TNFR2 polymorphism and any autoimmune diseases including SLE in Japanese.
AB - A polymorphism in high-affinity receptor of TNF (TNFR2) gene, Met196Arg, was reported to be associated with systemic lupus erythematosus (SLE) in Japanese, whereas the association could not be found in Europeans at all and this represents an apparent discrepancy. The association, then, should be tested in other populations to clarify the possible involvement, if any, of the TNFR2 polymorphism in SLE or other related autoimmune diseases. The purposes of this study were to examine the TNFR2 polymorphism in Japanese patients with SLE and to investigate its association with other autoimmune diseases accompanied by vasculitis, mixed connective tissue disease, Buerger's disease, and Takayasu's arteritis. We found no association at all between the TNFR2 polymorphism and any autoimmune diseases including SLE in Japanese.
UR - http://www.scopus.com/inward/record.url?scp=0035132963&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035132963&partnerID=8YFLogxK
U2 - 10.1034/j.1399-0039.2001.057001066.x
DO - 10.1034/j.1399-0039.2001.057001066.x
M3 - Article
C2 - 11169260
AN - SCOPUS:0035132963
VL - 57
SP - 66
EP - 69
JO - HLA
JF - HLA
SN - 2059-2302
IS - 1
ER -