Lactose-appended schizophyllan is a potential candidate as a hepatocyte-targeted antisense carrier

Teruaki Hasegawa, Mariko Umeda, Takahiro Matsumoto, Munenori Numata, Masami Mizu, Kazuya Koumoto, Kazuo Sakurai, Seiji Shinkai

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

A schizophyllan (β-1,3-glucan) derivative carrying lactose-appendages prepared by reductive amination can form stable macromolecular complexes with polynucleotides, shows excellent affinity with a lactose-binding lectin, and effectively mediates gene transfection into hepatocytes.

Original languageEnglish
Pages (from-to)382-383
Number of pages2
JournalChemical Communications
Volume4
Issue number4
DOIs
Publication statusPublished - Jan 1 2004

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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