Lactose-appended schizophyllan is a potential candidate as a hepatocyte-targeted antisense carrier

Teruaki Hasegawa, Mariko Umeda, Takahiro Matsumoto, Munenori Numata, Masami Mizu, Kazuya Koumoto, Kazuo Sakurai, Seiji Shinkai

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A schizophyllan (β-1,3-glucan) derivative carrying lactose-appendages prepared by reductive amination can form stable macromolecular complexes with polynucleotides, shows excellent affinity with a lactose-binding lectin, and effectively mediates gene transfection into hepatocytes.

Original languageEnglish
Pages (from-to)382-383
Number of pages2
JournalChemical Communications
Volume4
Issue number4
DOIs
Publication statusPublished - Jan 1 2004

Fingerprint

Sizofiran
Amination
Lactose
Genes
Derivatives
Macromolecular Substances
Polynucleotides
Glucans
Lectins
Hepatocytes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Lactose-appended schizophyllan is a potential candidate as a hepatocyte-targeted antisense carrier. / Hasegawa, Teruaki; Umeda, Mariko; Matsumoto, Takahiro; Numata, Munenori; Mizu, Masami; Koumoto, Kazuya; Sakurai, Kazuo; Shinkai, Seiji.

In: Chemical Communications, Vol. 4, No. 4, 01.01.2004, p. 382-383.

Research output: Contribution to journalArticle

Hasegawa, T, Umeda, M, Matsumoto, T, Numata, M, Mizu, M, Koumoto, K, Sakurai, K & Shinkai, S 2004, 'Lactose-appended schizophyllan is a potential candidate as a hepatocyte-targeted antisense carrier', Chemical Communications, vol. 4, no. 4, pp. 382-383. https://doi.org/10.1039/b313426a
Hasegawa, Teruaki ; Umeda, Mariko ; Matsumoto, Takahiro ; Numata, Munenori ; Mizu, Masami ; Koumoto, Kazuya ; Sakurai, Kazuo ; Shinkai, Seiji. / Lactose-appended schizophyllan is a potential candidate as a hepatocyte-targeted antisense carrier. In: Chemical Communications. 2004 ; Vol. 4, No. 4. pp. 382-383.
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