Lactose-appended schizophyllan is a potential candidate as a hepatocyte-targeted antisense carrier

Teruaki Hasegawa; Mariko Umeda; Takahiro Matsumoto; Munenori Numata; Masami Mizu; Kazuya Koumoto; Kazuo Sakurai; Seiji Shinkai

doi:10.1039/b313426a

Lactose-appended schizophyllan is a potential candidate as a hepatocyte-targeted antisense carrier

Teruaki Hasegawa, Mariko Umeda, Takahiro Matsumoto, Munenori Numata, Masami Mizu, Kazuya Koumoto, Kazuo Sakurai, Seiji Shinkai

Institute for Advanced Study

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

A schizophyllan (β-1,3-glucan) derivative carrying lactose-appendages prepared by reductive amination can form stable macromolecular complexes with polynucleotides, shows excellent affinity with a lactose-binding lectin, and effectively mediates gene transfection into hepatocytes.

Original language	English
Pages (from-to)	382-383
Number of pages	2
Journal	Chemical Communications
Volume	4
Issue number	4
DOIs	https://doi.org/10.1039/b313426a
Publication status	Published - Jan 1 2004

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/b313426a

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Lactose-appended schizophyllan is a potential candidate as a hepatocyte-targeted antisense carrier. / Hasegawa, Teruaki; Umeda, Mariko; Matsumoto, Takahiro; Numata, Munenori; Mizu, Masami; Koumoto, Kazuya; Sakurai, Kazuo; Shinkai, Seiji.

In: Chemical Communications, Vol. 4, No. 4, 01.01.2004, p. 382-383.

Research output: Contribution to journal › Article › peer-review

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Lactose-appended schizophyllan is a potential candidate as a hepatocyte-targeted antisense carrier

Abstract

All Science Journal Classification (ASJC) codes

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