Ladder-shaped polyether compound, desulfated yessotoxin, interacts with membrane-integral α-helix peptides

Megumi Mori; Tohru Oishi; Shigeru Matsuoka; Satoru Ujihara; Nobuaki Matsumori; Michio Murata; Masayuki Satake; Yasukatsu Oshima; Nobuto Matsushita; Saburo Aimoto

doi:10.1016/j.bmc.2005.05.039

Ladder-shaped polyether compound, desulfated yessotoxin, interacts with membrane-integral α-helix peptides

Megumi Mori, Tohru Oishi, Shigeru Matsuoka, Satoru Ujihara, Nobuaki Matsumori, Michio Murata, Masayuki Satake, Yasukatsu Oshima, Nobuto Matsushita, Saburo Aimoto

Research output: Contribution to journal › Article

27 Citations (Scopus)

Abstract

Ladder-shaped polyether compounds, represented by brevetoxins, ciguatoxins, maitotoxin, and prymnesins, are thought to possess the high affinity to transmembrane proteins. As a model compound of ladder-shaped polyethers, we adopted desulfated yessotoxin (2) and examined its interaction with glycopholin A, a membrane protein known to form a dimer or oligomer. Desulfated yessotoxin turned out to interact with the α-helix so as to induce the dissociation of glycopholin oligomers when examined by SDS and PFO gel electrophoresis. The results provided the first evidence that lapper-shaped polyethers interact with transmembrane helix domains.

Original language	English
Pages (from-to)	5099-5103
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry
Volume	13
Issue number	17
DOIs	https://doi.org/10.1016/j.bmc.2005.05.039
Publication status	Published - Sep 1 2005
Externally published	Yes

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All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Cite this

Mori, M., Oishi, T., Matsuoka, S., Ujihara, S., Matsumori, N., Murata, M., ... Aimoto, S. (2005). Ladder-shaped polyether compound, desulfated yessotoxin, interacts with membrane-integral α-helix peptides. Bioorganic and Medicinal Chemistry, 13(17), 5099-5103. https://doi.org/10.1016/j.bmc.2005.05.039

Ladder-shaped polyether compound, desulfated yessotoxin, interacts with membrane-integral α-helix peptides. / Mori, Megumi; Oishi, Tohru; Matsuoka, Shigeru; Ujihara, Satoru; Matsumori, Nobuaki; Murata, Michio; Satake, Masayuki; Oshima, Yasukatsu; Matsushita, Nobuto; Aimoto, Saburo.

In: Bioorganic and Medicinal Chemistry, Vol. 13, No. 17, 01.09.2005, p. 5099-5103.

Research output: Contribution to journal › Article

Mori, Megumi ; Oishi, Tohru ; Matsuoka, Shigeru ; Ujihara, Satoru ; Matsumori, Nobuaki ; Murata, Michio ; Satake, Masayuki ; Oshima, Yasukatsu ; Matsushita, Nobuto ; Aimoto, Saburo. / Ladder-shaped polyether compound, desulfated yessotoxin, interacts with membrane-integral α-helix peptides. In: Bioorganic and Medicinal Chemistry. 2005 ; Vol. 13, No. 17. pp. 5099-5103.

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AU - Matsumori, Nobuaki

AU - Murata, Michio

AU - Satake, Masayuki

AU - Oshima, Yasukatsu

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AU - Aimoto, Saburo

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Access to Document

10.1016/j.bmc.2005.05.039