@article{cac96a1b28c3407d833ac979cdd7e890,
title = "Laminar differences in the orientation selectivity of geniculate afferents in mouse primary visual cortex",
abstract = "It has been debated whether orientation selectivity in mouse primary visual cortex (V1) is derived from tuned lateral geniculate nucleus (LGN) inputs or computed from untuned LGN inputs. However, few studies have measured orientation tuning of LGN axons projecting to V1. We measured the response properties of mouse LGN axons terminating in V1 and found that LGN axons projecting to layer 4 were generally less tuned for orientation than axons projecting to more superficial layers of V1. We also found several differences in response properties between LGN axons and V1 neurons in layer 4. These results suggest that orientation selectivity of mouse V1 may not simply be inherited from LGN inputs, but could also depend on thalamocortical or V1 circuits.",
author = "Satoru Kondo and Kenichi Ohki",
note = "Funding Information: We thank T. Matsui for the technical advice at the beginning of the experiments, A. Honda for the assistance with the histology experiments, A. Honda and Y. Sono for animal care and genotyping, all of the members of Ohki laboratory for support and discussion, and the Research Support Center, Graduate School of Medical Sciences, Kyushu University for technical support. This work was supported by grants from CREST-JST (to K.O.), JSPS KAKENHI (grant number 25221001 to K.O.), JST, Strategic International Research Cooperative Program, SCIP (to K.O.), Grant-in-Aid for Scientific Research on Innovative Areas, “Glial assembly: a new regulatory machinery of brain function and disorders” (25117004 to K.O.). A part of this work was carried out under the Brain/MINDS by the MEXT of Japan. Publisher Copyright: {\textcopyright} 2016 Nature America, Inc. All rights reserved.",
year = "2016",
month = jan,
day = "27",
doi = "10.1038/nn.4215",
language = "English",
volume = "19",
pages = "316--319",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "2",
}