Laminar differences in the orientation selectivity of geniculate afferents in mouse primary visual cortex

Satoru Kondo, Kenichi Ohki

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

It has been debated whether orientation selectivity in mouse primary visual cortex (V1) is derived from tuned lateral geniculate nucleus (LGN) inputs or computed from untuned LGN inputs. However, few studies have measured orientation tuning of LGN axons projecting to V1. We measured the response properties of mouse LGN axons terminating in V1 and found that LGN axons projecting to layer 4 were generally less tuned for orientation than axons projecting to more superficial layers of V1. We also found several differences in response properties between LGN axons and V1 neurons in layer 4. These results suggest that orientation selectivity of mouse V1 may not simply be inherited from LGN inputs, but could also depend on thalamocortical or V1 circuits.

Original languageEnglish
Pages (from-to)316-319
Number of pages4
JournalNature Neuroscience
Volume19
Issue number2
DOIs
Publication statusPublished - Jan 27 2016

Fingerprint

Geniculate Bodies
Visual Cortex
Axons
Neurons

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Laminar differences in the orientation selectivity of geniculate afferents in mouse primary visual cortex. / Kondo, Satoru; Ohki, Kenichi.

In: Nature Neuroscience, Vol. 19, No. 2, 27.01.2016, p. 316-319.

Research output: Contribution to journalArticle

@article{cac96a1b28c3407d833ac979cdd7e890,
title = "Laminar differences in the orientation selectivity of geniculate afferents in mouse primary visual cortex",
abstract = "It has been debated whether orientation selectivity in mouse primary visual cortex (V1) is derived from tuned lateral geniculate nucleus (LGN) inputs or computed from untuned LGN inputs. However, few studies have measured orientation tuning of LGN axons projecting to V1. We measured the response properties of mouse LGN axons terminating in V1 and found that LGN axons projecting to layer 4 were generally less tuned for orientation than axons projecting to more superficial layers of V1. We also found several differences in response properties between LGN axons and V1 neurons in layer 4. These results suggest that orientation selectivity of mouse V1 may not simply be inherited from LGN inputs, but could also depend on thalamocortical or V1 circuits.",
author = "Satoru Kondo and Kenichi Ohki",
year = "2016",
month = "1",
day = "27",
doi = "10.1038/nn.4215",
language = "English",
volume = "19",
pages = "316--319",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - Laminar differences in the orientation selectivity of geniculate afferents in mouse primary visual cortex

AU - Kondo, Satoru

AU - Ohki, Kenichi

PY - 2016/1/27

Y1 - 2016/1/27

N2 - It has been debated whether orientation selectivity in mouse primary visual cortex (V1) is derived from tuned lateral geniculate nucleus (LGN) inputs or computed from untuned LGN inputs. However, few studies have measured orientation tuning of LGN axons projecting to V1. We measured the response properties of mouse LGN axons terminating in V1 and found that LGN axons projecting to layer 4 were generally less tuned for orientation than axons projecting to more superficial layers of V1. We also found several differences in response properties between LGN axons and V1 neurons in layer 4. These results suggest that orientation selectivity of mouse V1 may not simply be inherited from LGN inputs, but could also depend on thalamocortical or V1 circuits.

AB - It has been debated whether orientation selectivity in mouse primary visual cortex (V1) is derived from tuned lateral geniculate nucleus (LGN) inputs or computed from untuned LGN inputs. However, few studies have measured orientation tuning of LGN axons projecting to V1. We measured the response properties of mouse LGN axons terminating in V1 and found that LGN axons projecting to layer 4 were generally less tuned for orientation than axons projecting to more superficial layers of V1. We also found several differences in response properties between LGN axons and V1 neurons in layer 4. These results suggest that orientation selectivity of mouse V1 may not simply be inherited from LGN inputs, but could also depend on thalamocortical or V1 circuits.

UR - http://www.scopus.com/inward/record.url?scp=84956467441&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84956467441&partnerID=8YFLogxK

U2 - 10.1038/nn.4215

DO - 10.1038/nn.4215

M3 - Article

C2 - 26691830

AN - SCOPUS:84956467441

VL - 19

SP - 316

EP - 319

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 2

ER -