Laminin γ2 chain expression in squamous cell carcinomas of the tongue and its clinical relevance

Yuichiro Kuratomi, Mayuko Kumamoto, Ryuji Yasumatsu, Torahiko Nakashima, Muneyuki Masuda, Yoshihiko Kumamoto, Tomoya Yamamoto, Sohtaro Komiyama

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Laminin γ2 chain (LNγ2) expression and its clinical relevance were examined in squamous cell carcinomas of the tongue. When tumor cells were attached to each other and showed expansive growth, LNγ2 was expressed only in the peripheral cells of the tumor nests (peripheral expression). In contrast, when tumor cells showed infiltrative growth diminishing cell-cell adhesion, LNγ2 expression was diffusely observed in almost all of the cells (diffuse expression). Patients with caricinoma cells of the primary lesions showing peripheral LNγ2 expression were classified as the peripheral expression type, whereas patients with carcinoma cells showing diffuse LNγ2 expression at least in part of the invasive fronts were classified as the diffuse expression type. Among 30 patients with tongue carcinomas of more than stage II, 19 patients were the peripheral expression type and 11 patients were the diffuse expression type. The 3-year disease-specific survival rates for the peripheral type and diffuse type were 64% and 34%, respectively. LNγ2 may play an important role in growth and invasion of tongue carcinomas. In particular, it seems likely that the diffuse LNγ2 expression in carcinoma cells has a significant relevance to the malignant characteristics of infiltrative carcinoma cells. In addition, LNγ2 expression may be a useful prognostic factor for the patients with carcinomas of the tongue.

Original languageEnglish
Pages (from-to)653-657
Number of pages5
JournalJournal of Otolaryngology of Japan
Volume107
Issue number6
DOIs
Publication statusPublished - Jan 1 2004

Fingerprint

Laminin
Tongue
Squamous Cell Carcinoma
Carcinoma
Growth
Neoplasms
Cell Adhesion
Survival Rate

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Laminin γ2 chain expression in squamous cell carcinomas of the tongue and its clinical relevance. / Kuratomi, Yuichiro; Kumamoto, Mayuko; Yasumatsu, Ryuji; Nakashima, Torahiko; Masuda, Muneyuki; Kumamoto, Yoshihiko; Yamamoto, Tomoya; Komiyama, Sohtaro.

In: Journal of Otolaryngology of Japan, Vol. 107, No. 6, 01.01.2004, p. 653-657.

Research output: Contribution to journalArticle

Kuratomi, Y, Kumamoto, M, Yasumatsu, R, Nakashima, T, Masuda, M, Kumamoto, Y, Yamamoto, T & Komiyama, S 2004, 'Laminin γ2 chain expression in squamous cell carcinomas of the tongue and its clinical relevance', Journal of Otolaryngology of Japan, vol. 107, no. 6, pp. 653-657. https://doi.org/10.3950/jibiinkoka.107.653
Kuratomi, Yuichiro ; Kumamoto, Mayuko ; Yasumatsu, Ryuji ; Nakashima, Torahiko ; Masuda, Muneyuki ; Kumamoto, Yoshihiko ; Yamamoto, Tomoya ; Komiyama, Sohtaro. / Laminin γ2 chain expression in squamous cell carcinomas of the tongue and its clinical relevance. In: Journal of Otolaryngology of Japan. 2004 ; Vol. 107, No. 6. pp. 653-657.
@article{6129bd8a2ff24f968428462bdef9b73c,
title = "Laminin γ2 chain expression in squamous cell carcinomas of the tongue and its clinical relevance",
abstract = "Laminin γ2 chain (LNγ2) expression and its clinical relevance were examined in squamous cell carcinomas of the tongue. When tumor cells were attached to each other and showed expansive growth, LNγ2 was expressed only in the peripheral cells of the tumor nests (peripheral expression). In contrast, when tumor cells showed infiltrative growth diminishing cell-cell adhesion, LNγ2 expression was diffusely observed in almost all of the cells (diffuse expression). Patients with caricinoma cells of the primary lesions showing peripheral LNγ2 expression were classified as the peripheral expression type, whereas patients with carcinoma cells showing diffuse LNγ2 expression at least in part of the invasive fronts were classified as the diffuse expression type. Among 30 patients with tongue carcinomas of more than stage II, 19 patients were the peripheral expression type and 11 patients were the diffuse expression type. The 3-year disease-specific survival rates for the peripheral type and diffuse type were 64{\%} and 34{\%}, respectively. LNγ2 may play an important role in growth and invasion of tongue carcinomas. In particular, it seems likely that the diffuse LNγ2 expression in carcinoma cells has a significant relevance to the malignant characteristics of infiltrative carcinoma cells. In addition, LNγ2 expression may be a useful prognostic factor for the patients with carcinomas of the tongue.",
author = "Yuichiro Kuratomi and Mayuko Kumamoto and Ryuji Yasumatsu and Torahiko Nakashima and Muneyuki Masuda and Yoshihiko Kumamoto and Tomoya Yamamoto and Sohtaro Komiyama",
year = "2004",
month = "1",
day = "1",
doi = "10.3950/jibiinkoka.107.653",
language = "English",
volume = "107",
pages = "653--657",
journal = "Journal of Otolaryngology of Japan",
issn = "0030-6622",
publisher = "Oto-Rhino-Laryngological Society of Japan Inc.",
number = "6",

}

TY - JOUR

T1 - Laminin γ2 chain expression in squamous cell carcinomas of the tongue and its clinical relevance

AU - Kuratomi, Yuichiro

AU - Kumamoto, Mayuko

AU - Yasumatsu, Ryuji

AU - Nakashima, Torahiko

AU - Masuda, Muneyuki

AU - Kumamoto, Yoshihiko

AU - Yamamoto, Tomoya

AU - Komiyama, Sohtaro

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Laminin γ2 chain (LNγ2) expression and its clinical relevance were examined in squamous cell carcinomas of the tongue. When tumor cells were attached to each other and showed expansive growth, LNγ2 was expressed only in the peripheral cells of the tumor nests (peripheral expression). In contrast, when tumor cells showed infiltrative growth diminishing cell-cell adhesion, LNγ2 expression was diffusely observed in almost all of the cells (diffuse expression). Patients with caricinoma cells of the primary lesions showing peripheral LNγ2 expression were classified as the peripheral expression type, whereas patients with carcinoma cells showing diffuse LNγ2 expression at least in part of the invasive fronts were classified as the diffuse expression type. Among 30 patients with tongue carcinomas of more than stage II, 19 patients were the peripheral expression type and 11 patients were the diffuse expression type. The 3-year disease-specific survival rates for the peripheral type and diffuse type were 64% and 34%, respectively. LNγ2 may play an important role in growth and invasion of tongue carcinomas. In particular, it seems likely that the diffuse LNγ2 expression in carcinoma cells has a significant relevance to the malignant characteristics of infiltrative carcinoma cells. In addition, LNγ2 expression may be a useful prognostic factor for the patients with carcinomas of the tongue.

AB - Laminin γ2 chain (LNγ2) expression and its clinical relevance were examined in squamous cell carcinomas of the tongue. When tumor cells were attached to each other and showed expansive growth, LNγ2 was expressed only in the peripheral cells of the tumor nests (peripheral expression). In contrast, when tumor cells showed infiltrative growth diminishing cell-cell adhesion, LNγ2 expression was diffusely observed in almost all of the cells (diffuse expression). Patients with caricinoma cells of the primary lesions showing peripheral LNγ2 expression were classified as the peripheral expression type, whereas patients with carcinoma cells showing diffuse LNγ2 expression at least in part of the invasive fronts were classified as the diffuse expression type. Among 30 patients with tongue carcinomas of more than stage II, 19 patients were the peripheral expression type and 11 patients were the diffuse expression type. The 3-year disease-specific survival rates for the peripheral type and diffuse type were 64% and 34%, respectively. LNγ2 may play an important role in growth and invasion of tongue carcinomas. In particular, it seems likely that the diffuse LNγ2 expression in carcinoma cells has a significant relevance to the malignant characteristics of infiltrative carcinoma cells. In addition, LNγ2 expression may be a useful prognostic factor for the patients with carcinomas of the tongue.

UR - http://www.scopus.com/inward/record.url?scp=4344679616&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4344679616&partnerID=8YFLogxK

U2 - 10.3950/jibiinkoka.107.653

DO - 10.3950/jibiinkoka.107.653

M3 - Article

C2 - 15283174

AN - SCOPUS:4344679616

VL - 107

SP - 653

EP - 657

JO - Journal of Otolaryngology of Japan

JF - Journal of Otolaryngology of Japan

SN - 0030-6622

IS - 6

ER -