Laminin, a major basement membrane component of the blood vessel, as a negative regulator of osteoclastogenesis

T. Kukita, K. Hata, A. Kukita, T. Iijima

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Laminin, the major basement membrane glycoprotein of the blood vessel, inducing many cellular responses, inhibited the differentiation of osteoclasts in a rat bone marrow culture system when immobilized on the surface of the culture wells, showing that laminin acts as a negative regulator of osteoclast differentiation in a nonsolubilized form. Laminin inhibited the process of preosteoclast formation from early progenitor cells in bone marrow. This laminin-mediated inhibition of osteoclastogenesis was blocked by the addition of laminin fragment YIGSR, indicating that the inhibitory effect of laminin was mediated via laminin receptors. This finding suggests a significant role of basement membrane laminin of the blood vessels as a negative regulator of osteoclastogenesis.

Original languageEnglish
Pages (from-to)140-142
Number of pages3
JournalCalcified Tissue International
Volume63
Issue number2
DOIs
Publication statusPublished - Aug 1 1998

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

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