Laminin, a major basement membrane component of the blood vessel, as a negative regulator of osteoclastogenesis

Toshio Kukita, K. Hata, A. Kukita, T. Iijima

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Laminin, the major basement membrane glycoprotein of the blood vessel, inducing many cellular responses, inhibited the differentiation of osteoclasts in a rat bone marrow culture system when immobilized on the surface of the culture wells, showing that laminin acts as a negative regulator of osteoclast differentiation in a nonsolubilized form. Laminin inhibited the process of preosteoclast formation from early progenitor cells in bone marrow. This laminin-mediated inhibition of osteoclastogenesis was blocked by the addition of laminin fragment YIGSR, indicating that the inhibitory effect of laminin was mediated via laminin receptors. This finding suggests a significant role of basement membrane laminin of the blood vessels as a negative regulator of osteoclastogenesis.

Original languageEnglish
Pages (from-to)140-142
Number of pages3
JournalCalcified Tissue International
Volume63
Issue number2
DOIs
Publication statusPublished - Aug 1 1998

Fingerprint

Laminin
Basement Membrane
Osteogenesis
Blood Vessels
Osteoclasts
tyrosyl-isoleucyl-glycyl-seryl-arginine
Bone Marrow
Laminin Receptors
Membrane Glycoproteins
Stem Cells

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

Cite this

Laminin, a major basement membrane component of the blood vessel, as a negative regulator of osteoclastogenesis. / Kukita, Toshio; Hata, K.; Kukita, A.; Iijima, T.

In: Calcified Tissue International, Vol. 63, No. 2, 01.08.1998, p. 140-142.

Research output: Contribution to journalArticle

@article{e984c5dbed374d69ae092577651ad690,
title = "Laminin, a major basement membrane component of the blood vessel, as a negative regulator of osteoclastogenesis",
abstract = "Laminin, the major basement membrane glycoprotein of the blood vessel, inducing many cellular responses, inhibited the differentiation of osteoclasts in a rat bone marrow culture system when immobilized on the surface of the culture wells, showing that laminin acts as a negative regulator of osteoclast differentiation in a nonsolubilized form. Laminin inhibited the process of preosteoclast formation from early progenitor cells in bone marrow. This laminin-mediated inhibition of osteoclastogenesis was blocked by the addition of laminin fragment YIGSR, indicating that the inhibitory effect of laminin was mediated via laminin receptors. This finding suggests a significant role of basement membrane laminin of the blood vessels as a negative regulator of osteoclastogenesis.",
author = "Toshio Kukita and K. Hata and A. Kukita and T. Iijima",
year = "1998",
month = "8",
day = "1",
doi = "10.1007/s002239900504",
language = "English",
volume = "63",
pages = "140--142",
journal = "Calcified Tissue International",
issn = "0171-967X",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - Laminin, a major basement membrane component of the blood vessel, as a negative regulator of osteoclastogenesis

AU - Kukita, Toshio

AU - Hata, K.

AU - Kukita, A.

AU - Iijima, T.

PY - 1998/8/1

Y1 - 1998/8/1

N2 - Laminin, the major basement membrane glycoprotein of the blood vessel, inducing many cellular responses, inhibited the differentiation of osteoclasts in a rat bone marrow culture system when immobilized on the surface of the culture wells, showing that laminin acts as a negative regulator of osteoclast differentiation in a nonsolubilized form. Laminin inhibited the process of preosteoclast formation from early progenitor cells in bone marrow. This laminin-mediated inhibition of osteoclastogenesis was blocked by the addition of laminin fragment YIGSR, indicating that the inhibitory effect of laminin was mediated via laminin receptors. This finding suggests a significant role of basement membrane laminin of the blood vessels as a negative regulator of osteoclastogenesis.

AB - Laminin, the major basement membrane glycoprotein of the blood vessel, inducing many cellular responses, inhibited the differentiation of osteoclasts in a rat bone marrow culture system when immobilized on the surface of the culture wells, showing that laminin acts as a negative regulator of osteoclast differentiation in a nonsolubilized form. Laminin inhibited the process of preosteoclast formation from early progenitor cells in bone marrow. This laminin-mediated inhibition of osteoclastogenesis was blocked by the addition of laminin fragment YIGSR, indicating that the inhibitory effect of laminin was mediated via laminin receptors. This finding suggests a significant role of basement membrane laminin of the blood vessels as a negative regulator of osteoclastogenesis.

UR - http://www.scopus.com/inward/record.url?scp=0031870481&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031870481&partnerID=8YFLogxK

U2 - 10.1007/s002239900504

DO - 10.1007/s002239900504

M3 - Article

C2 - 9685519

AN - SCOPUS:0031870481

VL - 63

SP - 140

EP - 142

JO - Calcified Tissue International

JF - Calcified Tissue International

SN - 0171-967X

IS - 2

ER -