Lantibiotic nisin Z fermentative production by Lactococcus lactis 10-1: Relationship between production of the lantibiotic and lactate and cell growth

H. Matsusaki, N. Endo, Kenji Sonomoto, A. Ishizaki

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145 Citations (Scopus)

Abstract

The influence of several parameters on the fermentative production of nisin Z by Lactococcus lactis IO-1 was studied. Considerable attention has been focused on the relationship between the primary metabolite production of bacteriocin and lactate and cell growth, which has so far not been clarified in detail. Production of nisin Z was optimal at 30 C and in the pH range 5.0 5.5. The addition of Ca2+ to the medium showed a stimulating effect on the production of nisin Z. A maximum activity of 3150 IU/ml was obtained during pH-controlled batch fermentation in the medium supplemented with 0.1 M CaCl2. It was about three times higher than that obtained under the optimal conditions for cell growth and lactic acid production.

Original languageEnglish
Pages (from-to)36-40
Number of pages5
JournalApplied Microbiology and Biotechnology
Volume45
Issue number1-2
DOIs
Publication statusPublished - Jan 1 1996

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology

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