Lantibiotics: Insight and foresight for new paradigm

Jun ichi Nagao, Sikder M. Asaduzzaman, Yuji Aso, Ken ichi Okuda, Jiro Nakayama, Kenji Sonomoto

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Lantibiotics are a unique type of antimicrobial peptide produced by a large number of gram-positive bacteria that contain unusual amino acids, such as lanthionine and dehydrated amino acids. Ribosomally synthesized lantibiotic prepeptide consists of an N-terminal leader peptide followed by a C-terminal propeptide moiety that undergoes several post-translational modification events to yield a biologically active lantibiotic. Research on lantibiotics has drawn much attention in recent years and has undergone extensive progress as a step forward to the next paradigm. Unusual amino acids in lantibiotics solely contribute to their biological activity and also enhance their structural stability. Thus, enzymes involved in lantibiotic biosynthesis would have a high potential for peptide engineering by introducing unusual amino acids into desired peptides, which may establish a universal approach to advance the structural design of novel peptides, termed lantibiotic engineering. In this review, we focus on recent development with contemporary innovations and perspective of lantibiotic research.

Original languageEnglish
Pages (from-to)139-149
Number of pages11
JournalJournal of Bioscience and Bioengineering
Volume102
Issue number3
DOIs
Publication statusPublished - Sep 1 2006

Fingerprint

Bacteriocins
Peptides
Amino acids
Amino Acids
Biosynthesis
Bioactivity
Structural design
Bacteria
Enzymes
Innovation
Gram-Positive Bacteria
Post Translational Protein Processing
Protein Sorting Signals
Research

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

Cite this

Nagao, J. I., Asaduzzaman, S. M., Aso, Y., Okuda, K. I., Nakayama, J., & Sonomoto, K. (2006). Lantibiotics: Insight and foresight for new paradigm. Journal of Bioscience and Bioengineering, 102(3), 139-149. https://doi.org/10.1263/jbb.102.139

Lantibiotics : Insight and foresight for new paradigm. / Nagao, Jun ichi; Asaduzzaman, Sikder M.; Aso, Yuji; Okuda, Ken ichi; Nakayama, Jiro; Sonomoto, Kenji.

In: Journal of Bioscience and Bioengineering, Vol. 102, No. 3, 01.09.2006, p. 139-149.

Research output: Contribution to journalArticle

Nagao, JI, Asaduzzaman, SM, Aso, Y, Okuda, KI, Nakayama, J & Sonomoto, K 2006, 'Lantibiotics: Insight and foresight for new paradigm', Journal of Bioscience and Bioengineering, vol. 102, no. 3, pp. 139-149. https://doi.org/10.1263/jbb.102.139
Nagao, Jun ichi ; Asaduzzaman, Sikder M. ; Aso, Yuji ; Okuda, Ken ichi ; Nakayama, Jiro ; Sonomoto, Kenji. / Lantibiotics : Insight and foresight for new paradigm. In: Journal of Bioscience and Bioengineering. 2006 ; Vol. 102, No. 3. pp. 139-149.
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