Large granular lymphocytic leukaemia with a mixed T-cell/B-cell phenotype

Koichi Akashi, Tsunefumi Shibuya, Minoru Nakamura, Akiko Oogami, Mine Harada, Yoshiyuki Niho

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We report a case of large granular lymphocytic leukaemia (LGLL) with mixed T-cell/B-cell phenotypes. The LGLL cells expressed T-cell markers such as CD1, CD2, CD3, CD5, CD7, CD8 and CD57. The CD8+ LGLL cells expressed B- cell markers including CD20 and PCA-1, and a fraction of purified CD8+ LGLL cells secreted double isotypes of immunoglobulins (IgG-κ and IgA-κ). Both TCRB and IGH genes were clonally rearranged. The LGLL cells could be divided into at least three subpopulations that were cytogenetically distinct, and all subpopulations involved the 11q23. The expression of both T- and B-cell markers on the LGLL cells suggests the involvement of a putative common lymphoid progenitor in leukaemic transformation.

Original languageEnglish
Pages (from-to)291-294
Number of pages4
JournalBritish Journal of Haematology
Volume100
Issue number2
DOIs
Publication statusPublished - Apr 2 1998

Fingerprint

Large Granular Lymphocytic Leukemia
B-Lymphocytes
T-Lymphocytes
Phenotype
Lymphoid Progenitor Cells
Passive Cutaneous Anaphylaxis
Immunoglobulin Isotypes
Immunoglobulin A
Immunoglobulin G

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Large granular lymphocytic leukaemia with a mixed T-cell/B-cell phenotype. / Akashi, Koichi; Shibuya, Tsunefumi; Nakamura, Minoru; Oogami, Akiko; Harada, Mine; Niho, Yoshiyuki.

In: British Journal of Haematology, Vol. 100, No. 2, 02.04.1998, p. 291-294.

Research output: Contribution to journalArticle

Akashi, Koichi ; Shibuya, Tsunefumi ; Nakamura, Minoru ; Oogami, Akiko ; Harada, Mine ; Niho, Yoshiyuki. / Large granular lymphocytic leukaemia with a mixed T-cell/B-cell phenotype. In: British Journal of Haematology. 1998 ; Vol. 100, No. 2. pp. 291-294.
@article{aeb6f245735348d0ba7b0321f8ccecd0,
title = "Large granular lymphocytic leukaemia with a mixed T-cell/B-cell phenotype",
abstract = "We report a case of large granular lymphocytic leukaemia (LGLL) with mixed T-cell/B-cell phenotypes. The LGLL cells expressed T-cell markers such as CD1, CD2, CD3, CD5, CD7, CD8 and CD57. The CD8+ LGLL cells expressed B- cell markers including CD20 and PCA-1, and a fraction of purified CD8+ LGLL cells secreted double isotypes of immunoglobulins (IgG-κ and IgA-κ). Both TCRB and IGH genes were clonally rearranged. The LGLL cells could be divided into at least three subpopulations that were cytogenetically distinct, and all subpopulations involved the 11q23. The expression of both T- and B-cell markers on the LGLL cells suggests the involvement of a putative common lymphoid progenitor in leukaemic transformation.",
author = "Koichi Akashi and Tsunefumi Shibuya and Minoru Nakamura and Akiko Oogami and Mine Harada and Yoshiyuki Niho",
year = "1998",
month = "4",
day = "2",
doi = "10.1046/j.1365-2141.1998.00552.x",
language = "English",
volume = "100",
pages = "291--294",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Large granular lymphocytic leukaemia with a mixed T-cell/B-cell phenotype

AU - Akashi, Koichi

AU - Shibuya, Tsunefumi

AU - Nakamura, Minoru

AU - Oogami, Akiko

AU - Harada, Mine

AU - Niho, Yoshiyuki

PY - 1998/4/2

Y1 - 1998/4/2

N2 - We report a case of large granular lymphocytic leukaemia (LGLL) with mixed T-cell/B-cell phenotypes. The LGLL cells expressed T-cell markers such as CD1, CD2, CD3, CD5, CD7, CD8 and CD57. The CD8+ LGLL cells expressed B- cell markers including CD20 and PCA-1, and a fraction of purified CD8+ LGLL cells secreted double isotypes of immunoglobulins (IgG-κ and IgA-κ). Both TCRB and IGH genes were clonally rearranged. The LGLL cells could be divided into at least three subpopulations that were cytogenetically distinct, and all subpopulations involved the 11q23. The expression of both T- and B-cell markers on the LGLL cells suggests the involvement of a putative common lymphoid progenitor in leukaemic transformation.

AB - We report a case of large granular lymphocytic leukaemia (LGLL) with mixed T-cell/B-cell phenotypes. The LGLL cells expressed T-cell markers such as CD1, CD2, CD3, CD5, CD7, CD8 and CD57. The CD8+ LGLL cells expressed B- cell markers including CD20 and PCA-1, and a fraction of purified CD8+ LGLL cells secreted double isotypes of immunoglobulins (IgG-κ and IgA-κ). Both TCRB and IGH genes were clonally rearranged. The LGLL cells could be divided into at least three subpopulations that were cytogenetically distinct, and all subpopulations involved the 11q23. The expression of both T- and B-cell markers on the LGLL cells suggests the involvement of a putative common lymphoid progenitor in leukaemic transformation.

UR - http://www.scopus.com/inward/record.url?scp=0031935949&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031935949&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2141.1998.00552.x

DO - 10.1046/j.1365-2141.1998.00552.x

M3 - Article

C2 - 9488615

AN - SCOPUS:0031935949

VL - 100

SP - 291

EP - 294

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 2

ER -