Large granular lymphocytic leukaemia with a mixed T-cell/B-cell phenotype

Koichi Akashi, Tsunefumi Shibuya, Minoru Nakamura, Akiko Oogami, Mine Harada, Yoshiyuki Niho

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We report a case of large granular lymphocytic leukaemia (LGLL) with mixed T-cell/B-cell phenotypes. The LGLL cells expressed T-cell markers such as CD1, CD2, CD3, CD5, CD7, CD8 and CD57. The CD8+ LGLL cells expressed B- cell markers including CD20 and PCA-1, and a fraction of purified CD8+ LGLL cells secreted double isotypes of immunoglobulins (IgG-κ and IgA-κ). Both TCRB and IGH genes were clonally rearranged. The LGLL cells could be divided into at least three subpopulations that were cytogenetically distinct, and all subpopulations involved the 11q23. The expression of both T- and B-cell markers on the LGLL cells suggests the involvement of a putative common lymphoid progenitor in leukaemic transformation.

Original languageEnglish
Pages (from-to)291-294
Number of pages4
JournalBritish Journal of Haematology
Volume100
Issue number2
DOIs
Publication statusPublished - 1998

All Science Journal Classification (ASJC) codes

  • Hematology

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