Lateral and ventromedial hypothalamic influences on hepatic autonomic nerve activity in the rat

Hironobu Yoshimatsu, Akira Niijima, Yutaka Oomura, Toshihiko Katafuchi

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Effects of hypothalamic stimulation and lesion on hepatic autonomic nerve activity were investigated in anesthetized rats. Stimulation of the lateral hypothalamic area increased activity of the hepatic vagal nerve and decreased activity of the splanchnic nerve. Lesion of this area produced a rapid and strong reduction of vagal nerve activity and induced either an increase or a decrease of splanchnic nerve activity. In contrast, stimulation of the ventromedial hypothalamic nucleus produced a strong inhibition of vagal nerve activity and facilitation of splanchnic nerve activity. However, lesion of this nucleus facilitated or inhibited activities in both nerve branches. The functional significance of the relationship between the hypothalamus and the hepatic autonomic nerve in regulation of glucose metabolism in the liver are discussed.

Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalBrain Research Bulletin
Volume21
Issue number2
DOIs
Publication statusPublished - Aug 1988

Fingerprint

Autonomic Pathways
Splanchnic Nerves
Liver
Ventromedial Hypothalamic Nucleus
Lateral Hypothalamic Area
Hypothalamus
Glucose

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Lateral and ventromedial hypothalamic influences on hepatic autonomic nerve activity in the rat. / Yoshimatsu, Hironobu; Niijima, Akira; Oomura, Yutaka; Katafuchi, Toshihiko.

In: Brain Research Bulletin, Vol. 21, No. 2, 08.1988, p. 239-244.

Research output: Contribution to journalArticle

Yoshimatsu, Hironobu ; Niijima, Akira ; Oomura, Yutaka ; Katafuchi, Toshihiko. / Lateral and ventromedial hypothalamic influences on hepatic autonomic nerve activity in the rat. In: Brain Research Bulletin. 1988 ; Vol. 21, No. 2. pp. 239-244.
@article{66036e26a1754ce5b6412141e4f1e62f,
title = "Lateral and ventromedial hypothalamic influences on hepatic autonomic nerve activity in the rat",
abstract = "Effects of hypothalamic stimulation and lesion on hepatic autonomic nerve activity were investigated in anesthetized rats. Stimulation of the lateral hypothalamic area increased activity of the hepatic vagal nerve and decreased activity of the splanchnic nerve. Lesion of this area produced a rapid and strong reduction of vagal nerve activity and induced either an increase or a decrease of splanchnic nerve activity. In contrast, stimulation of the ventromedial hypothalamic nucleus produced a strong inhibition of vagal nerve activity and facilitation of splanchnic nerve activity. However, lesion of this nucleus facilitated or inhibited activities in both nerve branches. The functional significance of the relationship between the hypothalamus and the hepatic autonomic nerve in regulation of glucose metabolism in the liver are discussed.",
author = "Hironobu Yoshimatsu and Akira Niijima and Yutaka Oomura and Toshihiko Katafuchi",
year = "1988",
month = "8",
doi = "10.1016/0361-9230(88)90237-7",
language = "English",
volume = "21",
pages = "239--244",
journal = "Brain Research Bulletin",
issn = "0361-9230",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Lateral and ventromedial hypothalamic influences on hepatic autonomic nerve activity in the rat

AU - Yoshimatsu, Hironobu

AU - Niijima, Akira

AU - Oomura, Yutaka

AU - Katafuchi, Toshihiko

PY - 1988/8

Y1 - 1988/8

N2 - Effects of hypothalamic stimulation and lesion on hepatic autonomic nerve activity were investigated in anesthetized rats. Stimulation of the lateral hypothalamic area increased activity of the hepatic vagal nerve and decreased activity of the splanchnic nerve. Lesion of this area produced a rapid and strong reduction of vagal nerve activity and induced either an increase or a decrease of splanchnic nerve activity. In contrast, stimulation of the ventromedial hypothalamic nucleus produced a strong inhibition of vagal nerve activity and facilitation of splanchnic nerve activity. However, lesion of this nucleus facilitated or inhibited activities in both nerve branches. The functional significance of the relationship between the hypothalamus and the hepatic autonomic nerve in regulation of glucose metabolism in the liver are discussed.

AB - Effects of hypothalamic stimulation and lesion on hepatic autonomic nerve activity were investigated in anesthetized rats. Stimulation of the lateral hypothalamic area increased activity of the hepatic vagal nerve and decreased activity of the splanchnic nerve. Lesion of this area produced a rapid and strong reduction of vagal nerve activity and induced either an increase or a decrease of splanchnic nerve activity. In contrast, stimulation of the ventromedial hypothalamic nucleus produced a strong inhibition of vagal nerve activity and facilitation of splanchnic nerve activity. However, lesion of this nucleus facilitated or inhibited activities in both nerve branches. The functional significance of the relationship between the hypothalamus and the hepatic autonomic nerve in regulation of glucose metabolism in the liver are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0024162601&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024162601&partnerID=8YFLogxK

U2 - 10.1016/0361-9230(88)90237-7

DO - 10.1016/0361-9230(88)90237-7

M3 - Article

C2 - 3191410

AN - SCOPUS:0024162601

VL - 21

SP - 239

EP - 244

JO - Brain Research Bulletin

JF - Brain Research Bulletin

SN - 0361-9230

IS - 2

ER -