Lauroyl-l-aspartate decreased food intake and body temperature in neonatal chicks

E. Erwan, V. S. Chowdhury, K. Ito, M. Furuse

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

We hypothesized that the effects of l- and d-amino acids might be influenced when conjugated with fatty acid. Thus, the effects of oral administration of lauroyl-l-aspartate (Lau-L-Asp) as well as lauroyl-d-aspartate (Lau-D-Asp) were examined. In Experiment 1, oral administration of both Lau-L-Asp and Lau-D-Asp decreased food intake while L- or D-Asp did not influence food intake. Interestingly, only Lau-L-Asp decreased body temperature. Experiment 2 was conducted to determine whether non-conjugated mixture of L-Asp plus lauric acid has same effects under ad libitum feeding conditions. Lau-L-Asp decreased food intake and body temperature, but L-Asp plus lauric acid did not show any effect studied. In Experiment 3, we found that Lau-L-Asp declined food intake as well as time-dependently suppressed the body temperature in fasted chicks. However, L-Asp plus lauric acid did not show any effect. These results suggest that Lau-L-Asp may exert anorexigenic and hypothermic actions in chicks.

Original languageEnglish
Pages (from-to)7-11
Number of pages5
JournalPharmacology Biochemistry and Behavior
Volume113
DOIs
Publication statusPublished - 2013

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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