Leakage mechanism of irinotecan from water-in-oil-in-water (W/O/W) multiple emulsions

Eiichi Toorisaka, Yuko Kokazu, Noriho Kamiya, Masahiro Goto

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The leakage mechanism of the anticancer drug Irinotecan (CPT-11) from multiple W/O/W emulsions was investigated. The molecular structure of surfactants used for the preparation of the multiple emulsions affected the leakage rate of CPT-11. A sugar-long alkyl chain ester was effective in suppressing the drug release from the emulsions, because the surfactant reduces the mobility of inner aqueous droplets in emulsions. The leakage of drugs was deduced to be caused by the thin lamella membrane formed between the internal and external aqueous phases. The direction of water transportation was also an important factor in the degree of the drug release.

Original languageEnglish
Pages (from-to)294-298
Number of pages5
Journalkagaku kogaku ronbunshu
Volume29
Issue number2
DOIs
Publication statusPublished - Mar 2003

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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