Left lobe living donor liver transplantation in adults

Yuji Soejima, K. Shirabe, A. Taketomi, T. Yoshizumi, H. Uchiyama, T. Ikegami, M. Ninomiya, N. Harada, H. Ijichi, Y. Maehara

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Abstract

Adult left lobe (LL) living donor liver transplantation (LDLT) has not generally been recognized as a feasible procedure because of the problem of graft size. The objectives of this study were to assess the feasibility and short- and long-term results of adult LL LDLT in comparison with right lobe (RL) LDLT. Data on 200 consecutive LL LDLTs, including five retransplants, were retrospectively compared with those of 112 RL LDLTs, in terms of survival, complications and donor morbidity. The mean graft weight to standard volume ratio of LL grafts was 38.7% whereas that of RL grafts was 47.6% (p < 0.0001). The 1-, 5- and 10-year patient survival rates of LL LDLT were 85.6%, 77.9% and 69.5%, respectively, which were comparable to those of RL LDLT (89.8%, 71.3% and 70.7%, respectively). The incidence of small-for-size syndromewas higher in LL LDLT (19.5%) than in RL LDLT (7.1%) (p < 0.01). The overall donor morbidity rates were comparable between LL (36.0%) and RL (34.8%), whereas postoperative liver function tests and hospital stay were significantly better (p < 0.0001) in LL donors. In conclusion, adult LL LDLT has comparable outcomes to that of RL LDLT. LL LDLT is viable and is the first choice in adult LDLT.

Original languageEnglish
Pages (from-to)1877-1885
Number of pages9
JournalAmerican Journal of Transplantation
Volume12
Issue number7
DOIs
Publication statusPublished - Jul 2012

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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    Soejima, Y., Shirabe, K., Taketomi, A., Yoshizumi, T., Uchiyama, H., Ikegami, T., Ninomiya, M., Harada, N., Ijichi, H., & Maehara, Y. (2012). Left lobe living donor liver transplantation in adults. American Journal of Transplantation, 12(7), 1877-1885. https://doi.org/10.1111/j.1600-6143.2012.04022.x