TY - JOUR
T1 - Left ventricular global strain for estimating relaxation and filling pressure
T2 - A multicenter study
AU - Hayashi, Taichi
AU - Yamada, Satoshi
AU - Iwano, Hiroyuki
AU - Nakabachi, Masahiro
AU - Sakakibara, Mamoru
AU - Okada, Kazunori
AU - Murai, Daisuke
AU - Nishino, Hisao
AU - Kusunose, Kenya
AU - Watanabe, Kiyotaka
AU - Ishizu, Tomoko
AU - Wakami, Kazuaki
AU - Yamada, Hirotsugu
AU - Dohi, Kaoru
AU - Seo, Yoshihiro
AU - Ohte, Nobuyuki
AU - Mikami, Taisei
AU - Tsutsui, Hiroyuki
PY - 2016
Y1 - 2016
N2 - Background: Speckle-tracking echocardiography (STE)-derived parameters may have better correlation with left ventricular (LV) relaxation and filling pressure than tissue Doppler-derived parameters. However, it has not been elucidated which parameter – strain or strain rate – and which direction of myocardial deformation – longitudinal or circumferential – is the most useful marker of LV relaxation and filling pressure. Methods and Results: We conducted a prospective multicenter study and compared the correlation of tissue Doppler- and STE-derived parameters with the time constant of LV pressure decay (τ) and LV mean diastolic pressure (MDP) in 77 patients. The correlation of early-diastolic mitral annular velocity (e´) with τ was weak (r=−0.32, P<0.01), and that of peak longitudinal strain (LS) was the strongest (r=−0.45, P<0.001) among the STE-derived parameters. There was a modest correlation between LVMDP and the ratio of early-diastolic inflow velocity (E) to e´ (E/e´) (r=0.50, P<0.001). In contrast, the ratio of E to LS (E/LS) correlated strongly with LVMDP (r=0.70, P<0.001). The correlation of E/LS with LVMDP was significantly better than that for E/e´ (P<0.01). Receiver-operating characteristic analysis showed that E/LS had the largest area under the curve for distinguishing elevated LVMDP (E/LS 0.86, E/e´ 0.74, E/A 0.67). Conclusions: STE-derived longitudinal parameters correlated well with LV relaxation and filling pressure. In particular, E/LS could be more accurate than E/e´ for estimating LV filling pressure.
AB - Background: Speckle-tracking echocardiography (STE)-derived parameters may have better correlation with left ventricular (LV) relaxation and filling pressure than tissue Doppler-derived parameters. However, it has not been elucidated which parameter – strain or strain rate – and which direction of myocardial deformation – longitudinal or circumferential – is the most useful marker of LV relaxation and filling pressure. Methods and Results: We conducted a prospective multicenter study and compared the correlation of tissue Doppler- and STE-derived parameters with the time constant of LV pressure decay (τ) and LV mean diastolic pressure (MDP) in 77 patients. The correlation of early-diastolic mitral annular velocity (e´) with τ was weak (r=−0.32, P<0.01), and that of peak longitudinal strain (LS) was the strongest (r=−0.45, P<0.001) among the STE-derived parameters. There was a modest correlation between LVMDP and the ratio of early-diastolic inflow velocity (E) to e´ (E/e´) (r=0.50, P<0.001). In contrast, the ratio of E to LS (E/LS) correlated strongly with LVMDP (r=0.70, P<0.001). The correlation of E/LS with LVMDP was significantly better than that for E/e´ (P<0.01). Receiver-operating characteristic analysis showed that E/LS had the largest area under the curve for distinguishing elevated LVMDP (E/LS 0.86, E/e´ 0.74, E/A 0.67). Conclusions: STE-derived longitudinal parameters correlated well with LV relaxation and filling pressure. In particular, E/LS could be more accurate than E/e´ for estimating LV filling pressure.
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U2 - 10.1253/circj.CJ-16-0106
DO - 10.1253/circj.CJ-16-0106
M3 - Article
C2 - 27021934
AN - SCOPUS:84964199505
SN - 1346-9843
VL - 80
SP - 1163
EP - 1170
JO - Circulation Journal
JF - Circulation Journal
IS - 5
ER -