lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal

Chikara Meno, Akihiko Shimono, Yukio Saijoh, Kenta Yashiro, Kyoko Mochida, Sachiko Ohishi, Sumihare Noji, Hisato Kondoh, Hiroshi Hamada

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416 Citations (Scopus)

Abstract

lefty-1, lefty-2, and nodal are expressed on the left side of developing mouse embryos and are implicated in left-right (L-R) determination. The role of lefty-1 was examined by analyzing mutant mice lacking this gene. The lefty-1-deficient mice showed a variety of L-R positional defects in visceral organs. Unexpectedly, however, the most common feature of lefty-1(-/-) mice was thoracic left isomerism (rather than right isomerism). The lack of lefty- 1 resulted in bilateral expression of nodal, lefty-2, and Pitx2 (a homeobox gene normally expressed on the left side). These observations suggest that the role of lefty-1 is to restrict the expression of lefty-2 and nodal to the left side, and that lefty-2 or nodal encodes a signal for 'leftness'.

Original languageEnglish
Pages (from-to)287-297
Number of pages11
JournalCell
Volume94
Issue number3
DOIs
Publication statusPublished - Aug 7 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Meno, C., Shimono, A., Saijoh, Y., Yashiro, K., Mochida, K., Ohishi, S., Noji, S., Kondoh, H., & Hamada, H. (1998). lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell, 94(3), 287-297. https://doi.org/10.1016/S0092-8674(00)81472-5