TY - JOUR
T1 - lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal
AU - Meno, Chikara
AU - Shimono, Akihiko
AU - Saijoh, Yukio
AU - Yashiro, Kenta
AU - Mochida, Kyoko
AU - Ohishi, Sachiko
AU - Noji, Sumihare
AU - Kondoh, Hisato
AU - Hamada, Hiroshi
N1 - Funding Information:
We thank Atsusi Kuroiwa for mouse nodal cDNA, Hiroshi Sasaki and Yumiko Saga for Shh and HNF3β probes, and Elizabeth J. Robertson and members of the Hamada and Kondoh laboratories for valuable comments and discussion. This work was supported by grants from the Ministry of Education, Science, Sports, and Culture of Japan (to H. K.), a grant from Research for the Future Program (to S. N.), and a grant from CREST (Core Research for Evolutional Science and Technology) of the Japan Science and Technology Corporation (to H. H.). C. M. is a recipient of a fellowship from the Japan Society for the Promotion of Science for Japanese Junior Scientists.
PY - 1998/8/7
Y1 - 1998/8/7
N2 - lefty-1, lefty-2, and nodal are expressed on the left side of developing mouse embryos and are implicated in left-right (L-R) determination. The role of lefty-1 was examined by analyzing mutant mice lacking this gene. The lefty-1-deficient mice showed a variety of L-R positional defects in visceral organs. Unexpectedly, however, the most common feature of lefty-1(-/-) mice was thoracic left isomerism (rather than right isomerism). The lack of lefty- 1 resulted in bilateral expression of nodal, lefty-2, and Pitx2 (a homeobox gene normally expressed on the left side). These observations suggest that the role of lefty-1 is to restrict the expression of lefty-2 and nodal to the left side, and that lefty-2 or nodal encodes a signal for 'leftness'.
AB - lefty-1, lefty-2, and nodal are expressed on the left side of developing mouse embryos and are implicated in left-right (L-R) determination. The role of lefty-1 was examined by analyzing mutant mice lacking this gene. The lefty-1-deficient mice showed a variety of L-R positional defects in visceral organs. Unexpectedly, however, the most common feature of lefty-1(-/-) mice was thoracic left isomerism (rather than right isomerism). The lack of lefty- 1 resulted in bilateral expression of nodal, lefty-2, and Pitx2 (a homeobox gene normally expressed on the left side). These observations suggest that the role of lefty-1 is to restrict the expression of lefty-2 and nodal to the left side, and that lefty-2 or nodal encodes a signal for 'leftness'.
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U2 - 10.1016/S0092-8674(00)81472-5
DO - 10.1016/S0092-8674(00)81472-5
M3 - Article
C2 - 9708731
AN - SCOPUS:0032493876
SN - 0092-8674
VL - 94
SP - 287
EP - 297
JO - Cell
JF - Cell
IS - 3
ER -