Leptin gene therapy in the fight against diabetes

Yuqing Wang, Akihiro Asakawa, Akio Inui, Ken Ichiro Kosai

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Importance of the field: The incidence of diabetes is increasing worldwide, yet current treatments are not always effective for all patient or disease types. Areas covered in this review: Here, we summarize the biologic and clinical roles of leptin in diabetes, and discuss candidate viral vectors that may be employed in the clinical use of central leptin gene therapy for diabetes. What the reader will gain: We discuss how studies on leptin, a regulator of the insulinglucose axis, have significantly advanced our understanding of the roles of energy homeostasis and insulin resistance in the pathogeneses of metabolic syndrome and diabetes. Recent studies have demonstrated the long-term therapeutic effects of central leptin gene therapy in obesity and diabetes via decreased insulin resistance and increased glucose metabolism. Many of these studies have employed viral vectors, which afford high in vivo gene transduction efficiencies compared with non-viral vectors. Take home message: Adeno-associated viral vectors are particularly well suited for central leptin gene therapy owing to their low toxicity and ability to drive transgene expression for extended periods.

Original languageEnglish
Pages (from-to)1405-1414
Number of pages10
JournalExpert Opinion on Biological Therapy
Volume10
Issue number10
DOIs
Publication statusPublished - Oct 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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