Leptin Receptor

K. Takaya, Y. Ogawa, H. Masuzaki, N. Matsuoka, K. Hosoda, K. Nakao

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Leptin is a fat cell-derived satiety factor that regulates food intake and energy expenditure. Its effects are mediated by interactions with the leptin receptor (Ob-R) that is alternatively spliced to encode at least five isoforms(a-e), which are distributed in a wide range of tissues including the hypothalamus. Ob-R is a member of cytokine receptors and involves the JAK-STAT signal transduction system. We found Ob-R mutations in Zucker fatty rats and obese Koletsky rats and demonstrated that Ob-R dysfunction brings around hyperphagia and obesity. However we and others have not found any Ob-R mutation in human obese subjects.

Original languageEnglish
Pages (from-to)1925-1930
Number of pages6
JournalNippon rinsho. Japanese journal of clinical medicine
Volume56
Issue number7
Publication statusPublished - Jan 1 1998
Externally publishedYes

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Leptin Receptors
Zucker Rats
Hyperphagia
Mutation
Cytokine Receptors
Leptin
Adipocytes
Energy Metabolism
Hypothalamus
Signal Transduction
Protein Isoforms
Obesity
Eating

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Takaya, K., Ogawa, Y., Masuzaki, H., Matsuoka, N., Hosoda, K., & Nakao, K. (1998). Leptin Receptor. Nippon rinsho. Japanese journal of clinical medicine, 56(7), 1925-1930.

Leptin Receptor. / Takaya, K.; Ogawa, Y.; Masuzaki, H.; Matsuoka, N.; Hosoda, K.; Nakao, K.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 56, No. 7, 01.01.1998, p. 1925-1930.

Research output: Contribution to journalReview article

Takaya, K, Ogawa, Y, Masuzaki, H, Matsuoka, N, Hosoda, K & Nakao, K 1998, 'Leptin Receptor', Nippon rinsho. Japanese journal of clinical medicine, vol. 56, no. 7, pp. 1925-1930.
Takaya K, Ogawa Y, Masuzaki H, Matsuoka N, Hosoda K, Nakao K. Leptin Receptor. Nippon rinsho. Japanese journal of clinical medicine. 1998 Jan 1;56(7):1925-1930.
Takaya, K. ; Ogawa, Y. ; Masuzaki, H. ; Matsuoka, N. ; Hosoda, K. ; Nakao, K. / Leptin Receptor. In: Nippon rinsho. Japanese journal of clinical medicine. 1998 ; Vol. 56, No. 7. pp. 1925-1930.
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