Lessons from comparative analysis of species-specific imprinted genes

K. Okamura, Takashi Ito

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Genomic imprinting is generally believed to be conserved in all mammals except for egg-laying monotremes, suggesting that it is closely related to placental and fetal growth. As expected, the imprinting status of most imprinted genes is conserved between mouse and human, and some are imprinted even in marsupials. On the other hand, a small number of genes were reported to exhibit species-specific imprinting that is not necessarily accounted for by either the placenta or conflict hypotheses. Since mouse and human represent a single, phylogenetically restricted clade in the mammalian class, a much broader comparison including mammals diverged earlier than rodents is necessary to fully understand the species-specificity and variation in evolution of genomic imprinting. Indeed, comparative analysis of a species-specific imprinted gene Impact using a broader range of mammals led us to propose an alternative dosage control hypothesis for the evolution of genomic imprinting.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalCytogenetic and Genome Research
Volume113
Issue number1-4
DOIs
Publication statusPublished - Mar 1 2006

Fingerprint

Genomic Imprinting
Mammals
Genes
Species Specificity
Marsupialia
Fetal Development
Placenta
Ovum
Rodentia

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Lessons from comparative analysis of species-specific imprinted genes. / Okamura, K.; Ito, Takashi.

In: Cytogenetic and Genome Research, Vol. 113, No. 1-4, 01.03.2006, p. 159-164.

Research output: Contribution to journalArticle

@article{101b3e4c800a4689a16209d6c8038924,
title = "Lessons from comparative analysis of species-specific imprinted genes",
abstract = "Genomic imprinting is generally believed to be conserved in all mammals except for egg-laying monotremes, suggesting that it is closely related to placental and fetal growth. As expected, the imprinting status of most imprinted genes is conserved between mouse and human, and some are imprinted even in marsupials. On the other hand, a small number of genes were reported to exhibit species-specific imprinting that is not necessarily accounted for by either the placenta or conflict hypotheses. Since mouse and human represent a single, phylogenetically restricted clade in the mammalian class, a much broader comparison including mammals diverged earlier than rodents is necessary to fully understand the species-specificity and variation in evolution of genomic imprinting. Indeed, comparative analysis of a species-specific imprinted gene Impact using a broader range of mammals led us to propose an alternative dosage control hypothesis for the evolution of genomic imprinting.",
author = "K. Okamura and Takashi Ito",
year = "2006",
month = "3",
day = "1",
doi = "10.1159/000090828",
language = "English",
volume = "113",
pages = "159--164",
journal = "Cytogenetic and Genome Research",
issn = "1424-8581",
publisher = "S. Karger AG",
number = "1-4",

}

TY - JOUR

T1 - Lessons from comparative analysis of species-specific imprinted genes

AU - Okamura, K.

AU - Ito, Takashi

PY - 2006/3/1

Y1 - 2006/3/1

N2 - Genomic imprinting is generally believed to be conserved in all mammals except for egg-laying monotremes, suggesting that it is closely related to placental and fetal growth. As expected, the imprinting status of most imprinted genes is conserved between mouse and human, and some are imprinted even in marsupials. On the other hand, a small number of genes were reported to exhibit species-specific imprinting that is not necessarily accounted for by either the placenta or conflict hypotheses. Since mouse and human represent a single, phylogenetically restricted clade in the mammalian class, a much broader comparison including mammals diverged earlier than rodents is necessary to fully understand the species-specificity and variation in evolution of genomic imprinting. Indeed, comparative analysis of a species-specific imprinted gene Impact using a broader range of mammals led us to propose an alternative dosage control hypothesis for the evolution of genomic imprinting.

AB - Genomic imprinting is generally believed to be conserved in all mammals except for egg-laying monotremes, suggesting that it is closely related to placental and fetal growth. As expected, the imprinting status of most imprinted genes is conserved between mouse and human, and some are imprinted even in marsupials. On the other hand, a small number of genes were reported to exhibit species-specific imprinting that is not necessarily accounted for by either the placenta or conflict hypotheses. Since mouse and human represent a single, phylogenetically restricted clade in the mammalian class, a much broader comparison including mammals diverged earlier than rodents is necessary to fully understand the species-specificity and variation in evolution of genomic imprinting. Indeed, comparative analysis of a species-specific imprinted gene Impact using a broader range of mammals led us to propose an alternative dosage control hypothesis for the evolution of genomic imprinting.

UR - http://www.scopus.com/inward/record.url?scp=33645458989&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645458989&partnerID=8YFLogxK

U2 - 10.1159/000090828

DO - 10.1159/000090828

M3 - Article

C2 - 16575176

AN - SCOPUS:33645458989

VL - 113

SP - 159

EP - 164

JO - Cytogenetic and Genome Research

JF - Cytogenetic and Genome Research

SN - 1424-8581

IS - 1-4

ER -