TY - JOUR
T1 - Lessons from SARS
T2 - Control of acute lung failure by the SARS receptor ACE2
AU - Kuba, Keiji
AU - Imai, Yumiko
AU - Rao, Shuan
AU - Jiang, Chengyu
AU - Penninger, Josef M.
N1 - Funding Information:
Acknowledgements We thank M.J. Crackower, R. Sarao, and many others for their contributions. Supported by grants from The National Bank of Austria, The Austrian Ministry of Science and Education, IMBA, and EUGeneHeart to JMP. K.K. is supported by a Marie Curie Fellowship from the EU.
PY - 2006/10
Y1 - 2006/10
N2 - Angiotensin-converting enzyme 2 (ACE2), a second angiotensin-converting enzyme (ACE), regulates the renin-angiotensin system by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular systems. Recently, it has been shown that severe acute respiratory syndrome (SARS) coronavirus, the cause of SARS, utilizes ACE2 as an essential receptor for cell fusion and in vivo infections in mice. Intriguingly, ACE2 acts as a protective factor in various experimental models of acute lung failure and, therefore, acts not only as a key determinant for SARS virus entry into cells but also contributes to SARS pathogenesis. Here we review the role of ACE2 in disease pathogenesis, including lung diseases and cardiovascular diseases.
AB - Angiotensin-converting enzyme 2 (ACE2), a second angiotensin-converting enzyme (ACE), regulates the renin-angiotensin system by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular systems. Recently, it has been shown that severe acute respiratory syndrome (SARS) coronavirus, the cause of SARS, utilizes ACE2 as an essential receptor for cell fusion and in vivo infections in mice. Intriguingly, ACE2 acts as a protective factor in various experimental models of acute lung failure and, therefore, acts not only as a key determinant for SARS virus entry into cells but also contributes to SARS pathogenesis. Here we review the role of ACE2 in disease pathogenesis, including lung diseases and cardiovascular diseases.
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U2 - 10.1007/s00109-006-0094-9
DO - 10.1007/s00109-006-0094-9
M3 - Review article
C2 - 16988814
AN - SCOPUS:33749183557
SN - 0946-2716
VL - 84
SP - 814
EP - 820
JO - Klinische Wochenschrift
JF - Klinische Wochenschrift
IS - 10
ER -
