Leukaemia hijacks a neural mechanism to invade the central nervous system

Hisayuki Yao, Trevor T. Price, Gaia Cantelli, Brandon Ngo, Matthew J. Warner, Lindsey Olivere, Sarah M. Ridge, Elizabeth M. Jablonski, Joseph Therrien, Stacey Tannheimer, Chad M. McCall, Anjen Chenn, Dorothy A. Sipkins

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Acute lymphoblastic leukaemia (ALL) has a marked propensity to metastasize to the central nervous system (CNS). In contrast to brain metastases from solid tumours, metastases of ALL seldom involve the parenchyma but are isolated to the leptomeninges, which is an infrequent site for carcinomatous invasion. Although metastasis to the CNS occurs across all subtypes of ALL, a unifying mechanism for invasion has not yet been determined. Here we show that ALL cells in the circulation are unable to breach the blood–brain barrier in mice; instead, they migrate into the CNS along vessels that pass directly between vertebral or calvarial bone marrow and the subarachnoid space. The basement membrane of these bridging vessels is enriched in laminin, which is known to coordinate pathfinding of neuronal progenitor cells in the CNS. The laminin receptor α6 integrin is expressed in most cases of ALL. We found that α6 integrin–laminin interactions mediated the migration of ALL cells towards the cerebrospinal fluid in vitro. Mice with ALL xenografts were treated with either a PI3Kδ inhibitor, which decreased α6 integrin expression on ALL cells, or specific α6 integrin-neutralizing antibodies and showed significant reductions in ALL transit along bridging vessels, blast counts in the cerebrospinal fluid and CNS disease symptoms despite minimally decreased bone marrow disease burden. Our data suggest that α6 integrin expression, which is common in ALL, allows cells to use neural migratory pathways to invade the CNS.

Original languageEnglish
Pages (from-to)55-60
Number of pages6
JournalNature
Volume560
Issue number7716
DOIs
Publication statusPublished - Aug 2 2018
Externally publishedYes

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Central Nervous System
Integrins
Neoplasm Metastasis
Cerebrospinal Fluid
Bone Marrow Diseases
Laminin Receptors
Neural Pathways
Subarachnoid Space
Central Nervous System Diseases
Laminin
Neutralizing Antibodies
Phosphatidylinositol 3-Kinases
Basement Membrane
Heterografts
Neoplasms
Stem Cells
Bone Marrow
Brain

All Science Journal Classification (ASJC) codes

  • General

Cite this

Yao, H., Price, T. T., Cantelli, G., Ngo, B., Warner, M. J., Olivere, L., ... Sipkins, D. A. (2018). Leukaemia hijacks a neural mechanism to invade the central nervous system. Nature, 560(7716), 55-60. https://doi.org/10.1038/s41586-018-0342-5

Leukaemia hijacks a neural mechanism to invade the central nervous system. / Yao, Hisayuki; Price, Trevor T.; Cantelli, Gaia; Ngo, Brandon; Warner, Matthew J.; Olivere, Lindsey; Ridge, Sarah M.; Jablonski, Elizabeth M.; Therrien, Joseph; Tannheimer, Stacey; McCall, Chad M.; Chenn, Anjen; Sipkins, Dorothy A.

In: Nature, Vol. 560, No. 7716, 02.08.2018, p. 55-60.

Research output: Contribution to journalArticle

Yao, H, Price, TT, Cantelli, G, Ngo, B, Warner, MJ, Olivere, L, Ridge, SM, Jablonski, EM, Therrien, J, Tannheimer, S, McCall, CM, Chenn, A & Sipkins, DA 2018, 'Leukaemia hijacks a neural mechanism to invade the central nervous system', Nature, vol. 560, no. 7716, pp. 55-60. https://doi.org/10.1038/s41586-018-0342-5
Yao H, Price TT, Cantelli G, Ngo B, Warner MJ, Olivere L et al. Leukaemia hijacks a neural mechanism to invade the central nervous system. Nature. 2018 Aug 2;560(7716):55-60. https://doi.org/10.1038/s41586-018-0342-5
Yao, Hisayuki ; Price, Trevor T. ; Cantelli, Gaia ; Ngo, Brandon ; Warner, Matthew J. ; Olivere, Lindsey ; Ridge, Sarah M. ; Jablonski, Elizabeth M. ; Therrien, Joseph ; Tannheimer, Stacey ; McCall, Chad M. ; Chenn, Anjen ; Sipkins, Dorothy A. / Leukaemia hijacks a neural mechanism to invade the central nervous system. In: Nature. 2018 ; Vol. 560, No. 7716. pp. 55-60.
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