Leukoencephalopathy in HTLV-I-associated myelopathy: MRI and EEG data

Jun ichi Kira, Sei ichiro Minato, Yasuto Itoyama, Ikuo Goto, Motohiro Kato, Kanehiro Hasuo

Research output: Contribution to journalArticle

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Abstract

Magnetic resonance imaging (MRI) of the brain and electroencephalography (EEG) were carried out for patients with human T-lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM). Nineteen of 22 patients (86%) had abnormalities on brain MRI and/or EEG. Thirteen patients showed high signal intensity lesions scattered in the cerebral white matter, as seen on the T2-weighted MRI images. The lesions were mostly located in the subcortical and deep cerebral white matter and were not contiguous with the lateral ventricles. Patients with abnormalities on the brain MRI had a longer duration of disease and a greater disability than did those without MRI abnormalities. The EEG records showed definite abnormalities in 9, and minor abnormalities in 5. All patients with HAM for more than 5 years showed definite evidence of cerebral involvement. Our findings strongly suggest that a multifocal pathological process over the entire CNS is probably a common occurrence in HAM.

Original languageEnglish
Pages (from-to)221-232
Number of pages12
JournalJournal of the Neurological Sciences
Volume87
Issue number2-3
DOIs
Publication statusPublished - Nov 1988

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Leukoencephalopathies
Spinal Cord Diseases
Electroencephalography
Magnetic Resonance Imaging
Viruses
Tropical Spastic Paraparesis
Brain
Lateral Ventricles
Pathologic Processes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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Leukoencephalopathy in HTLV-I-associated myelopathy : MRI and EEG data. / Kira, Jun ichi; Minato, Sei ichiro; Itoyama, Yasuto; Goto, Ikuo; Kato, Motohiro; Hasuo, Kanehiro.

In: Journal of the Neurological Sciences, Vol. 87, No. 2-3, 11.1988, p. 221-232.

Research output: Contribution to journalArticle

Kira, Jun ichi ; Minato, Sei ichiro ; Itoyama, Yasuto ; Goto, Ikuo ; Kato, Motohiro ; Hasuo, Kanehiro. / Leukoencephalopathy in HTLV-I-associated myelopathy : MRI and EEG data. In: Journal of the Neurological Sciences. 1988 ; Vol. 87, No. 2-3. pp. 221-232.
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