TY - JOUR
T1 - Lewis base assisted Brønsted base catalysis
T2 - Bidentate phosphine oxides as activators and modulators of brønsted basic lanthanum-aryloxides
AU - Morimoto, Hiroyuki
AU - Yoshino, Tatsuhiko
AU - Yukawa, Takafumi
AU - Lu, Gang
AU - Matsunaga, Shigeki
AU - Shibasaki, Masakatsu
PY - 2008/11/10
Y1 - 2008/11/10
N2 - (Chemical Equation Presented) Dynamic Duo: A Lewis basic bidentate phosphine oxide was effective for activating and modulating the properties of Brønsted basic lanthanum aryl oxides. The Lewis base 1/lanthanum aryl oxide system was suitable for anti-selective Mannich-type reactions of trichloromethyl ketones (see scheme), affording unique building blocks for azetidine-2-carboxylic acids as well as β-amino acids.
AB - (Chemical Equation Presented) Dynamic Duo: A Lewis basic bidentate phosphine oxide was effective for activating and modulating the properties of Brønsted basic lanthanum aryl oxides. The Lewis base 1/lanthanum aryl oxide system was suitable for anti-selective Mannich-type reactions of trichloromethyl ketones (see scheme), affording unique building blocks for azetidine-2-carboxylic acids as well as β-amino acids.
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U2 - 10.1002/anie.200803682
DO - 10.1002/anie.200803682
M3 - Article
C2 - 18925596
AN - SCOPUS:56249148856
SN - 1433-7851
VL - 47
SP - 9125
EP - 9129
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 47
ER -