Lewis base assisted Brønsted base catalysis: Bidentate phosphine oxides as activators and modulators of brønsted basic lanthanum-aryloxides

Hiroyuki Morimoto, Tatsuhiko Yoshino, Takafumi Yukawa, Gang Lu, Shigeki Matsunaga, Masakatsu Shibasaki

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

(Chemical Equation Presented) Dynamic Duo: A Lewis basic bidentate phosphine oxide was effective for activating and modulating the properties of Brønsted basic lanthanum aryl oxides. The Lewis base 1/lanthanum aryl oxide system was suitable for anti-selective Mannich-type reactions of trichloromethyl ketones (see scheme), affording unique building blocks for azetidine-2-carboxylic acids as well as β-amino acids.

Original languageEnglish
Pages (from-to)9125-9129
Number of pages5
JournalAngewandte Chemie - International Edition
Volume47
Issue number47
DOIs
Publication statusPublished - Nov 10 2008
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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