Ligand accelerated indium(III)-catalyzed asymmetric alkynylation of aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor

Shinji Harada; Ryo Takita; Takashi Ohshima; Shigeki Matsunaga; Masakatsu Shibasaki

doi:10.1039/b614958h

Ligand accelerated indium(III)-catalyzed asymmetric alkynylation of aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor

Shinji Harada, Ryo Takita, Takashi Ohshima, Shigeki Matsunaga, Masakatsu Shibasaki

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

Indium(III)-catalyzed asymmetric alkynylation of aryl, heteroaryl, alkyl and alkenyl aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor was realized, and products were obtained in moderate to good yields (up to 97%) and high enantioselectivities (up to 99% ee) using 2-10 mol% of catalyst.

Original language	English
Pages (from-to)	948-950
Number of pages	3
Journal	Chemical Communications
Issue number	9
DOIs	https://doi.org/10.1039/b614958h
Publication status	Published - Jan 1 2007
Externally published	Yes

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/b614958h

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abstract = "Indium(III)-catalyzed asymmetric alkynylation of aryl, heteroaryl, alkyl and alkenyl aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor was realized, and products were obtained in moderate to good yields (up to 97%) and high enantioselectivities (up to 99% ee) using 2-10 mol% of catalyst.",

author = "Shinji Harada and Ryo Takita and Takashi Ohshima and Shigeki Matsunaga and Masakatsu Shibasaki",

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AU - Harada, Shinji

AU - Takita, Ryo

AU - Ohshima, Takashi

AU - Matsunaga, Shigeki

AU - Shibasaki, Masakatsu

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Indium(III)-catalyzed asymmetric alkynylation of aryl, heteroaryl, alkyl and alkenyl aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor was realized, and products were obtained in moderate to good yields (up to 97%) and high enantioselectivities (up to 99% ee) using 2-10 mol% of catalyst.

AB - Indium(III)-catalyzed asymmetric alkynylation of aryl, heteroaryl, alkyl and alkenyl aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor was realized, and products were obtained in moderate to good yields (up to 97%) and high enantioselectivities (up to 99% ee) using 2-10 mol% of catalyst.

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DO - 10.1039/b614958h

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Ligand accelerated indium(III)-catalyzed asymmetric alkynylation of aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor

Abstract

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