Ligand-inducible formation of RNA pseudoknot

Saki Matsumoto; Changfeng Hong; Takahiro Otabe; Asako Murata; Kazuhiko Nakatani

doi:10.1016/j.bmcl.2013.04.037

Ligand-inducible formation of RNA pseudoknot

Saki Matsumoto, Changfeng Hong, Takahiro Otabe, Asako Murata, Kazuhiko Nakatani

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Here, we demonstrate that a series of naphthyridine derivatives, naphthyridine carbamate tetramer (NCTn), can bind to the RNA CGG/CGG triad comprised of two single-stranded regions of a hairpin loop and a tail. Complete suppression of the binding by a single mutation indicated simultaneous binding of NCTn between hairpin loop and single stranded tail, leading to the formation of NCTn-induced pseudoknot.

Original language	English
Pages (from-to)	3539-3541
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	23
Issue number	12
DOIs	https://doi.org/10.1016/j.bmcl.2013.04.037
Publication status	Published - Jun 15 2013
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmcl.2013.04.037

Cite this

@article{c0ce56cf2c4d4b8b93284a98f96abce1,

title = "Ligand-inducible formation of RNA pseudoknot",

abstract = "Here, we demonstrate that a series of naphthyridine derivatives, naphthyridine carbamate tetramer (NCTn), can bind to the RNA CGG/CGG triad comprised of two single-stranded regions of a hairpin loop and a tail. Complete suppression of the binding by a single mutation indicated simultaneous binding of NCTn between hairpin loop and single stranded tail, leading to the formation of NCTn-induced pseudoknot.",

author = "Saki Matsumoto and Changfeng Hong and Takahiro Otabe and Asako Murata and Kazuhiko Nakatani",

note = "Funding Information: This work was supported by the Advanced Research for Medical Products Mining Program of the National Institute of Biomedical Innovation (NIBIO, 10-22 ). ",

year = "2013",

month = jun,

day = "15",

doi = "10.1016/j.bmcl.2013.04.037",

language = "English",

volume = "23",

pages = "3539--3541",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "12",

}

TY - JOUR

T1 - Ligand-inducible formation of RNA pseudoknot

AU - Matsumoto, Saki

AU - Hong, Changfeng

AU - Otabe, Takahiro

AU - Murata, Asako

AU - Nakatani, Kazuhiko

N1 - Funding Information: This work was supported by the Advanced Research for Medical Products Mining Program of the National Institute of Biomedical Innovation (NIBIO, 10-22 ).

PY - 2013/6/15

Y1 - 2013/6/15

N2 - Here, we demonstrate that a series of naphthyridine derivatives, naphthyridine carbamate tetramer (NCTn), can bind to the RNA CGG/CGG triad comprised of two single-stranded regions of a hairpin loop and a tail. Complete suppression of the binding by a single mutation indicated simultaneous binding of NCTn between hairpin loop and single stranded tail, leading to the formation of NCTn-induced pseudoknot.

AB - Here, we demonstrate that a series of naphthyridine derivatives, naphthyridine carbamate tetramer (NCTn), can bind to the RNA CGG/CGG triad comprised of two single-stranded regions of a hairpin loop and a tail. Complete suppression of the binding by a single mutation indicated simultaneous binding of NCTn between hairpin loop and single stranded tail, leading to the formation of NCTn-induced pseudoknot.

UR - http://www.scopus.com/inward/record.url?scp=84878106221&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878106221&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2013.04.037

DO - 10.1016/j.bmcl.2013.04.037

M3 - Article

C2 - 23664873

AN - SCOPUS:84878106221

SN - 0960-894X

VL - 23

SP - 3539

EP - 3541

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 12

ER -

Ligand-inducible formation of RNA pseudoknot

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this