Light-assisted oxidation of single-wall carbon nanohorns for abundant creation of oxygenated groups that enable Chemical modifications with proteins to enhance biocompatibility

Minfang Zhang, Masako Yudasaka, Kumiko Ajima, Jin Miyawaki, Sumio Iijima

Research output: Contribution to journalArticlepeer-review

98 Citations (Scopus)

Abstract

We show that light-assisted oxidation with hydrogen peroxide effectively and rapidly opens holes in carbon nanohorn walls and, more importantly, creates abundant oxygenated groups such as carboxylic groups at the hole edges. These oxygenated groups reacted with the protein bovine serum albumin. The obtained conjugates were highly dispersed in phosphate-buffered saline and were taken up by cultured mammalian cells via an endocytosis pathway.

Original languageEnglish
Pages (from-to)265-272
Number of pages8
JournalACS nano
Volume1
Issue number4
DOIs
Publication statusPublished - Nov 1 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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