Light-induced hormone conversion of T4 to T3 regulates photoperiodic response of gonads in birds

Takashi Yoshimura, Shinobu Yasuo, Miwa Watanabe, Masayuki Iigo, Takashi Yamamura, Kanjun Hirunagi, Shizufumi Ebihara

Research output: Contribution to journalArticle

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Abstract

Reproduction of many temperate zone birds is under photoperiodic control. The Japanese quail is an excellent model for studying the mechanism of photoperiodic time measurement because of its distinct and marked response to changing photoperiods. Studies on this animal have suggested that the mediobasal hypothalamus (MBH) is an important centre controlling photoperiodic time measurement. Here we report that expression in the MBH of the gene encoding type 2 iodothyronine deiodinase (Dio2), which catalyses the intracellular deiodination of thyroxine (T4) prohormone to the active 3,5,3′-triiodothyronine (T3), is induced by light in Japanese quail. Intracerebroventricular administration of T3 mimics the photoperiodic response, whereas the Dio2 inhibitor iopanoic acid prevents gonadal growth. These findings demonstrate that light-induced Dio2 expression in the MBH may be involved in the photoperiodic response of gonads in Japanese quail.

Original languageEnglish
Pages (from-to)178-181
Number of pages4
JournalNature
Volume426
Issue number6963
DOIs
Publication statusPublished - Nov 13 2003

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Coturnix
Gonads
Hypothalamus
Birds
Hormones
Light
Iopanoic Acid
Iodide Peroxidase
Photoperiod
Triiodothyronine
Thyroxine
Reproduction
Growth
Genes

All Science Journal Classification (ASJC) codes

  • General

Cite this

Yoshimura, T., Yasuo, S., Watanabe, M., Iigo, M., Yamamura, T., Hirunagi, K., & Ebihara, S. (2003). Light-induced hormone conversion of T4 to T3 regulates photoperiodic response of gonads in birds. Nature, 426(6963), 178-181. https://doi.org/10.1038/nature02117

Light-induced hormone conversion of T4 to T3 regulates photoperiodic response of gonads in birds. / Yoshimura, Takashi; Yasuo, Shinobu; Watanabe, Miwa; Iigo, Masayuki; Yamamura, Takashi; Hirunagi, Kanjun; Ebihara, Shizufumi.

In: Nature, Vol. 426, No. 6963, 13.11.2003, p. 178-181.

Research output: Contribution to journalArticle

Yoshimura, T, Yasuo, S, Watanabe, M, Iigo, M, Yamamura, T, Hirunagi, K & Ebihara, S 2003, 'Light-induced hormone conversion of T4 to T3 regulates photoperiodic response of gonads in birds', Nature, vol. 426, no. 6963, pp. 178-181. https://doi.org/10.1038/nature02117
Yoshimura T, Yasuo S, Watanabe M, Iigo M, Yamamura T, Hirunagi K et al. Light-induced hormone conversion of T4 to T3 regulates photoperiodic response of gonads in birds. Nature. 2003 Nov 13;426(6963):178-181. https://doi.org/10.1038/nature02117
Yoshimura, Takashi ; Yasuo, Shinobu ; Watanabe, Miwa ; Iigo, Masayuki ; Yamamura, Takashi ; Hirunagi, Kanjun ; Ebihara, Shizufumi. / Light-induced hormone conversion of T4 to T3 regulates photoperiodic response of gonads in birds. In: Nature. 2003 ; Vol. 426, No. 6963. pp. 178-181.
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