Abstract
New flavins with metal affinity, (1) and (2) were applied to photo-oxidation of alcohols and mandelate. (1) rapidly photo-oxidized alcohols in the presence of Mg(II) and Zn(II): the rate augmentation corresponds to 16-18 fold. (2) could photo-oxidize PhCH(OH)COO-K+ but only slightly PhCH(OH)COO-NMe4 +: the rate difference amounts to 110-fold. Thus, the photo-oxidizability of these modified flavins can be markedly improved through complexation with metal ions.
| Original language | English |
|---|---|
| Pages (from-to) | 5295-5298 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 25 |
| Issue number | 46 |
| DOIs | |
| Publication status | Published - Jan 1 1984 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Shinkai, S., Nakao, H., Ueda, K., & Manabe, O. (1984). Light-mediated oxidation of alcohols and mandelate by flavin-metal complexes. Tetrahedron Letters, 25(46), 5295-5298. https://doi.org/10.1016/S0040-4039(01)81587-2