Lineage relationship analysis of RORγt+ innate lymphoid cells

Shinichiro Sawa, Marie Cherrier, Matthias Lochner, Naoko Satoh-Takayama, Hans Jörg Fehling, Francina Langa, James P. Di Santo, Gérard Eberl

Research output: Contribution to journalArticle

319 Citations (Scopus)

Abstract

Lymphoid tissue - inducer (LTi) cells initiate the development of lymphoid tissues through the activation of local stromal cells in a process similar to inflammation. LTi cells express the nuclear hormone receptor RORγt, which also directs the expression of the proinflammatory cytokine interleukin-17 in T cells. We show here that LTi cells are part of a larger family of proinflammatory RORγt+ innate lymphoid cells (ILCs) that differentiate from distinct fetal liver RORγt+ precursors. The fate of RORγt+ ILCs is determined by mouse age, and after birth, favors the generation of cells involved in intestinal homeostasis and defense. Contrary to RORγt+ T cells, however, RORγt + ILCs develop in the absence of microbiota. Our study indicates that RORγt+ ILCs evolve to preempt intestinal colonization by microbial symbionts.

Original languageEnglish
Pages (from-to)665-669
Number of pages5
JournalScience
Volume330
Issue number6004
DOIs
Publication statusPublished - Oct 29 2010

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Lymphoid Tissue
Helper-Inducer T-Lymphocytes
Lymphocytes
T-Lymphocytes
Interleukin-17
Microbiota
Cytoplasmic and Nuclear Receptors
Stromal Cells
Homeostasis
Parturition
Cytokines
Inflammation
Liver

All Science Journal Classification (ASJC) codes

  • General

Cite this

Sawa, S., Cherrier, M., Lochner, M., Satoh-Takayama, N., Fehling, H. J., Langa, F., ... Eberl, G. (2010). Lineage relationship analysis of RORγt+ innate lymphoid cells. Science, 330(6004), 665-669. https://doi.org/10.1126/science.1194597

Lineage relationship analysis of RORγt+ innate lymphoid cells. / Sawa, Shinichiro; Cherrier, Marie; Lochner, Matthias; Satoh-Takayama, Naoko; Fehling, Hans Jörg; Langa, Francina; Di Santo, James P.; Eberl, Gérard.

In: Science, Vol. 330, No. 6004, 29.10.2010, p. 665-669.

Research output: Contribution to journalArticle

Sawa, S, Cherrier, M, Lochner, M, Satoh-Takayama, N, Fehling, HJ, Langa, F, Di Santo, JP & Eberl, G 2010, 'Lineage relationship analysis of RORγt+ innate lymphoid cells', Science, vol. 330, no. 6004, pp. 665-669. https://doi.org/10.1126/science.1194597
Sawa S, Cherrier M, Lochner M, Satoh-Takayama N, Fehling HJ, Langa F et al. Lineage relationship analysis of RORγt+ innate lymphoid cells. Science. 2010 Oct 29;330(6004):665-669. https://doi.org/10.1126/science.1194597
Sawa, Shinichiro ; Cherrier, Marie ; Lochner, Matthias ; Satoh-Takayama, Naoko ; Fehling, Hans Jörg ; Langa, Francina ; Di Santo, James P. ; Eberl, Gérard. / Lineage relationship analysis of RORγt+ innate lymphoid cells. In: Science. 2010 ; Vol. 330, No. 6004. pp. 665-669.
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