Lineage relationship analysis of RORγt+ innate lymphoid cells

Shinichiro Sawa, Marie Cherrier, Matthias Lochner, Naoko Satoh-Takayama, Hans Jörg Fehling, Francina Langa, James P. Di Santo, Gérard Eberl

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343 Citations (Scopus)

Abstract

Lymphoid tissue - inducer (LTi) cells initiate the development of lymphoid tissues through the activation of local stromal cells in a process similar to inflammation. LTi cells express the nuclear hormone receptor RORγt, which also directs the expression of the proinflammatory cytokine interleukin-17 in T cells. We show here that LTi cells are part of a larger family of proinflammatory RORγt+ innate lymphoid cells (ILCs) that differentiate from distinct fetal liver RORγt+ precursors. The fate of RORγt+ ILCs is determined by mouse age, and after birth, favors the generation of cells involved in intestinal homeostasis and defense. Contrary to RORγt+ T cells, however, RORγt + ILCs develop in the absence of microbiota. Our study indicates that RORγt+ ILCs evolve to preempt intestinal colonization by microbial symbionts.

Original languageEnglish
Pages (from-to)665-669
Number of pages5
JournalScience
Volume330
Issue number6004
DOIs
Publication statusPublished - Oct 29 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

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    Sawa, S., Cherrier, M., Lochner, M., Satoh-Takayama, N., Fehling, H. J., Langa, F., Di Santo, J. P., & Eberl, G. (2010). Lineage relationship analysis of RORγt+ innate lymphoid cells. Science, 330(6004), 665-669. https://doi.org/10.1126/science.1194597