Lipid radicals cause light-induced retinal degeneration

Masataka Enoki; Saki Shinto; Yuta Matsuoka; Ayasa Otsuka; Sachiko Kaidzu; Masaki Tanito; Takahiro Shibata; Koji Uchida; Akihiro Ohira; Mayumi Yamato; Ken-Ichi Yamada

doi:10.1039/c7cc03387g

Lipid radicals cause light-induced retinal degeneration

Masataka Enoki, Saki Shinto, Yuta Matsuoka, Ayasa Otsuka, Sachiko Kaidzu, Masaki Tanito, Takahiro Shibata, Koji Uchida, Akihiro Ohira, Mayumi Yamato, Ken-Ichi Yamada

Molecular Bioinformatics

Research output: Contribution to journal › Article › peer-review

Abstract

Age-related macular degeneration (AMD) is the leading cause of blindness worldwide. Although the cause of AMD remains unknown, lipid peroxidation (LPO) end-products are critical molecules for its development. Herein, we report the imaging of lipid radicals, which are key factors in the LPO reaction, and therapeutic information using animal models.

Original language	English
Journal	Chemical Communications
DOIs	https://doi.org/10.1039/c7cc03387g
Publication status	E-pub ahead of print - Sep 20 2017

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title = "Lipid radicals cause light-induced retinal degeneration",

abstract = "Age-related macular degeneration (AMD) is the leading cause of blindness worldwide. Although the cause of AMD remains unknown, lipid peroxidation (LPO) end-products are critical molecules for its development. Herein, we report the imaging of lipid radicals, which are key factors in the LPO reaction, and therapeutic information using animal models.",

author = "Masataka Enoki and Saki Shinto and Yuta Matsuoka and Ayasa Otsuka and Sachiko Kaidzu and Masaki Tanito and Takahiro Shibata and Koji Uchida and Akihiro Ohira and Mayumi Yamato and Ken-Ichi Yamada",

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journal = "Chemical Communications",

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AU - Enoki, Masataka

AU - Shinto, Saki

AU - Matsuoka, Yuta

AU - Otsuka, Ayasa

AU - Kaidzu, Sachiko

AU - Tanito, Masaki

AU - Shibata, Takahiro

AU - Uchida, Koji

AU - Ohira, Akihiro

AU - Yamato, Mayumi

AU - Yamada, Ken-Ichi

PY - 2017/9/20

Y1 - 2017/9/20

N2 - Age-related macular degeneration (AMD) is the leading cause of blindness worldwide. Although the cause of AMD remains unknown, lipid peroxidation (LPO) end-products are critical molecules for its development. Herein, we report the imaging of lipid radicals, which are key factors in the LPO reaction, and therapeutic information using animal models.

AB - Age-related macular degeneration (AMD) is the leading cause of blindness worldwide. Although the cause of AMD remains unknown, lipid peroxidation (LPO) end-products are critical molecules for its development. Herein, we report the imaging of lipid radicals, which are key factors in the LPO reaction, and therapeutic information using animal models.

U2 - 10.1039/c7cc03387g

DO - 10.1039/c7cc03387g

M3 - Article

C2 - 28930310

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

ER -