Lipid radicals cause light-induced retinal degeneration

Masataka Enoki; Saki Shinto; Yuta Matsuoka; Ayasa Otsuka; Sachiko Kaidzu; Masaki Tanito; Takahiro Shibata; Koji Uchida; Akihiro Ohira; Mayumi Yamato; Ken-Ichi Yamada

doi:10.1039/c7cc03387g

Lipid radicals cause light-induced retinal degeneration

Masataka Enoki, Saki Shinto, Yuta Matsuoka, Ayasa Otsuka, Sachiko Kaidzu, Masaki Tanito, Takahiro Shibata, Koji Uchida, Akihiro Ohira, Mayumi Yamato, Ken-Ichi Yamada

Molecular Bioinformatics

Research output: Contribution to journal › Article

Abstract

Age-related macular degeneration (AMD) is the leading cause of blindness worldwide. Although the cause of AMD remains unknown, lipid peroxidation (LPO) end-products are critical molecules for its development. Herein, we report the imaging of lipid radicals, which are key factors in the LPO reaction, and therapeutic information using animal models.

Original language	English
Journal	Chemical Communications
DOIs	https://doi.org/10.1039/c7cc03387g
Publication status	E-pub ahead of print - Sep 20 2017

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Enoki, M., Shinto, S., Matsuoka, Y., Otsuka, A., Kaidzu, S., Tanito, M., ... Yamada, K-I. (2017). Lipid radicals cause light-induced retinal degeneration. Chemical Communications. https://doi.org/10.1039/c7cc03387g

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abstract = "Age-related macular degeneration (AMD) is the leading cause of blindness worldwide. Although the cause of AMD remains unknown, lipid peroxidation (LPO) end-products are critical molecules for its development. Herein, we report the imaging of lipid radicals, which are key factors in the LPO reaction, and therapeutic information using animal models.",

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AU - Enoki, Masataka

AU - Shinto, Saki

AU - Matsuoka, Yuta

AU - Otsuka, Ayasa

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AU - Tanito, Masaki

AU - Shibata, Takahiro

AU - Uchida, Koji

AU - Ohira, Akihiro

AU - Yamato, Mayumi

AU - Yamada, Ken-Ichi

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AB - Age-related macular degeneration (AMD) is the leading cause of blindness worldwide. Although the cause of AMD remains unknown, lipid peroxidation (LPO) end-products are critical molecules for its development. Herein, we report the imaging of lipid radicals, which are key factors in the LPO reaction, and therapeutic information using animal models.

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10.1039/c7cc03387g