Lipid radicals cause light-induced retinal degeneration

Masataka Enoki; Saki Shinto; Yuta Matsuoka; Ayasa Otsuka; Sachiko Kaidzu; Masaki Tanito; Takahiro Shibata; Koji Uchida; Akihiro Ohira; Mayumi Yamato; Ken Ichi Yamada

doi:10.1039/c7cc03387g

Lipid radicals cause light-induced retinal degeneration

Masataka Enoki, Saki Shinto, Yuta Matsuoka, Ayasa Otsuka, Sachiko Kaidzu, Masaki Tanito, Takahiro Shibata, Koji Uchida, Akihiro Ohira, Mayumi Yamato, Ken Ichi Yamada

Molecular Bioinformatics

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Age-related macular degeneration (AMD) is the leading cause of blindness worldwide. Although the cause of AMD remains unknown, lipid peroxidation (LPO) end-products are critical molecules for its development. Herein, we report the imaging of lipid radicals, which are key factors in the LPO reaction, and therapeutic information using animal models.

Original language	English
Pages (from-to)	10922-10925
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	79
DOIs	https://doi.org/10.1039/c7cc03387g
Publication status	Published - 2017

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c7cc03387g

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Lipid radicals cause light-induced retinal degeneration. / Enoki, Masataka; Shinto, Saki; Matsuoka, Yuta; Otsuka, Ayasa; Kaidzu, Sachiko; Tanito, Masaki; Shibata, Takahiro; Uchida, Koji; Ohira, Akihiro; Yamato, Mayumi; Yamada, Ken Ichi.

In: Chemical Communications, Vol. 53, No. 79, 2017, p. 10922-10925.

Research output: Contribution to journal › Article › peer-review

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title = "Lipid radicals cause light-induced retinal degeneration",

abstract = "Age-related macular degeneration (AMD) is the leading cause of blindness worldwide. Although the cause of AMD remains unknown, lipid peroxidation (LPO) end-products are critical molecules for its development. Herein, we report the imaging of lipid radicals, which are key factors in the LPO reaction, and therapeutic information using animal models.",

author = "Masataka Enoki and Saki Shinto and Yuta Matsuoka and Ayasa Otsuka and Sachiko Kaidzu and Masaki Tanito and Takahiro Shibata and Koji Uchida and Akihiro Ohira and Mayumi Yamato and Yamada, {Ken Ichi}",

note = "Funding Information: This work was supported in part by JST PRESTO, JSPS KAKENHI grant numbers 16H01363 and 16K15109, the Platform Project for Supporting Drug Discovery and Life Science Research from the AMED, and the ONO Medical Research Foundation, Japan. We appreciate the technical support provided by the Research Support Center, Graduate School of Medical Sciences, Kyushu University. We thank J. Ludovic Croxford, PhD, from the Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript.",

year = "2017",

doi = "10.1039/c7cc03387g",

language = "English",

volume = "53",

pages = "10922--10925",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T1 - Lipid radicals cause light-induced retinal degeneration

AU - Enoki, Masataka

AU - Shinto, Saki

AU - Matsuoka, Yuta

AU - Otsuka, Ayasa

AU - Kaidzu, Sachiko

AU - Tanito, Masaki

AU - Shibata, Takahiro

AU - Uchida, Koji

AU - Ohira, Akihiro

AU - Yamato, Mayumi

AU - Yamada, Ken Ichi

N1 - Funding Information: This work was supported in part by JST PRESTO, JSPS KAKENHI grant numbers 16H01363 and 16K15109, the Platform Project for Supporting Drug Discovery and Life Science Research from the AMED, and the ONO Medical Research Foundation, Japan. We appreciate the technical support provided by the Research Support Center, Graduate School of Medical Sciences, Kyushu University. We thank J. Ludovic Croxford, PhD, from the Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript.

PY - 2017

Y1 - 2017

N2 - Age-related macular degeneration (AMD) is the leading cause of blindness worldwide. Although the cause of AMD remains unknown, lipid peroxidation (LPO) end-products are critical molecules for its development. Herein, we report the imaging of lipid radicals, which are key factors in the LPO reaction, and therapeutic information using animal models.

AB - Age-related macular degeneration (AMD) is the leading cause of blindness worldwide. Although the cause of AMD remains unknown, lipid peroxidation (LPO) end-products are critical molecules for its development. Herein, we report the imaging of lipid radicals, which are key factors in the LPO reaction, and therapeutic information using animal models.

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DO - 10.1039/c7cc03387g

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JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 79

ER -

Lipid radicals cause light-induced retinal degeneration

Abstract

All Science Journal Classification (ASJC) codes

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