TY - JOUR
T1 - Lipid signaling in chemotherapy-induced peripheral neuropathy
AU - Yamamoto, Shota
AU - Egashira, Nobuaki
N1 - Funding Information:
This work was supported by the Japan Society for the Promotion of Science KAKENHI grants JP21K15309 (S.Y.) and JP21K06670 (N.E.) . S.Y. was a JSPS research fellow (JP21J00759). The sponsors had no role in study design, in the collection, analysis, and interpretation of data, in the writing of the report, or in the decision to submit the article for publication. The authors would like to thank Editage ( www.editage.com ) for English language editing.
Funding Information:
This work was supported by the Japan Society for the Promotion of Science KAKENHI grants JP21K15309 (S.Y.) and JP21K06670 (N.E.). S.Y. was a JSPS research fellow (JP21J00759). The sponsors had no role in study design, in the collection, analysis, and interpretation of data, in the writing of the report, or in the decision to submit the article for publication. The authors would like to thank Editage (www.editage.com) for English language editing.
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/12
Y1 - 2021/12
N2 - Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most debilitating adverse effects observed in patients with cancer treated with neurotoxic anticancer drugs. However, there are few options for the prevention and treatment of CIPN. Lipids play essential roles in the body, as structural membrane components, energy sources, signaling molecules, and body surface barriers. Recent improvements in analytical tools and methods relevant to endogenous lipids have enabled investigation of the diverse nature of lipids in normal physiology and pathology, including their roles in acting as activators of ion channels and endogenous ligands of G protein-coupled receptors and how they affect membrane protein conformation. In this report, we summarize the crucial roles of lipid signaling in CIPN pathology.
AB - Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most debilitating adverse effects observed in patients with cancer treated with neurotoxic anticancer drugs. However, there are few options for the prevention and treatment of CIPN. Lipids play essential roles in the body, as structural membrane components, energy sources, signaling molecules, and body surface barriers. Recent improvements in analytical tools and methods relevant to endogenous lipids have enabled investigation of the diverse nature of lipids in normal physiology and pathology, including their roles in acting as activators of ion channels and endogenous ligands of G protein-coupled receptors and how they affect membrane protein conformation. In this report, we summarize the crucial roles of lipid signaling in CIPN pathology.
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U2 - 10.1016/j.cotox.2021.08.007
DO - 10.1016/j.cotox.2021.08.007
M3 - Review article
AN - SCOPUS:85122651027
SN - 2468-2020
VL - 28
SP - 1
EP - 6
JO - Current Opinion in Toxicology
JF - Current Opinion in Toxicology
ER -
