Lipopolysaccharide-Induced Monocytic Cell Death for the Diagnosis of Mild Neonatal-Onset Multisystem Inflammatory Disease

Hidetoshi Takada, Masataka Ishimura, Hiroko Inada, Shouichi Ohga, Koichi Kusuhara, Yoichi Moroi, Masutaka Furue, Toshiro Hara

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this report, we describe a boy who showed mild symptoms of neonatal-onset multisystem inflammatory disease. Although his symptoms and laboratory findings were similar to those of systemic juvenile idiopathic arthritis, further examinations revealed papilledema, meningitis, and a NLRP3 mutation. His peripheral blood monocytes died within 24 hours after lipopolysaccharide stimulation, a test that may be useful for diagnosis even in mild cases.

Original languageEnglish
Pages (from-to)885-887.e1
JournalJournal of Pediatrics
Volume152
Issue number6
DOIs
Publication statusPublished - Jun 2008

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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