Lipopolysaccharide-Induced Monocytic Cell Death for the Diagnosis of Mild Neonatal-Onset Multisystem Inflammatory Disease

Hidetoshi Takada, Masataka Ishimura, Hiroko Inada, Shouichi Ohga, Koichi Kusuhara, Yoichi Moroi, Masutaka Furue, Toshiro Hara

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this report, we describe a boy who showed mild symptoms of neonatal-onset multisystem inflammatory disease. Although his symptoms and laboratory findings were similar to those of systemic juvenile idiopathic arthritis, further examinations revealed papilledema, meningitis, and a NLRP3 mutation. His peripheral blood monocytes died within 24 hours after lipopolysaccharide stimulation, a test that may be useful for diagnosis even in mild cases.

Original languageEnglish
Pages (from-to)885-887.e1
JournalJournal of Pediatrics
Volume152
Issue number6
DOIs
Publication statusPublished - Jun 2008

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Cryopyrin-Associated Periodic Syndromes
Papilledema
Juvenile Arthritis
Meningitis
Lipopolysaccharides
Monocytes
Cell Death
Mutation

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Lipopolysaccharide-Induced Monocytic Cell Death for the Diagnosis of Mild Neonatal-Onset Multisystem Inflammatory Disease. / Takada, Hidetoshi; Ishimura, Masataka; Inada, Hiroko; Ohga, Shouichi; Kusuhara, Koichi; Moroi, Yoichi; Furue, Masutaka; Hara, Toshiro.

In: Journal of Pediatrics, Vol. 152, No. 6, 06.2008, p. 885-887.e1.

Research output: Contribution to journalArticle

Takada, Hidetoshi ; Ishimura, Masataka ; Inada, Hiroko ; Ohga, Shouichi ; Kusuhara, Koichi ; Moroi, Yoichi ; Furue, Masutaka ; Hara, Toshiro. / Lipopolysaccharide-Induced Monocytic Cell Death for the Diagnosis of Mild Neonatal-Onset Multisystem Inflammatory Disease. In: Journal of Pediatrics. 2008 ; Vol. 152, No. 6. pp. 885-887.e1.
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