Lipoprotein metabolism, insulin resistance, and adipocytokine levels in Japanese female adolescents with a normal body mass index and high body fat mass

Noriaki Kishimoto, Koichi Okita, Shingo Takada, Ichiro Sakuma, Yasuaki Saijo, Hitoshi Chiba, Kojiro Ishii, Reiko Kishi, Hiroyuki Tsutsui

Research output: Contribution to journalArticle

6 Citations (Scopus)


Background: The prevalence of obesity is gradually increasing in Japan, but in women aged in their 20 s to 50 s it has been disproportionately decreasing. However, the exact body composition of this subset of the population has not been elucidated. Methods and Results: Body composition was determined using whole-body dual energy X-ray absorptiometry and metabolic parameters in 157 Japanese female university students (21.1±1.9 years); 31 women had a normal body mass index (BMI), but an increased body fat mass (BFM). Only the 31 had signifcantly higher low-density lipoprotein-cholesterol levels (90.5 vs 99.0 mg/dl, P<0.01) and leptin concentration (7.0 vs 4.6 ng/ml, P<0.05) and lower high-density lipoprotein-cholesterol (80.4±15.1 vs 73.5±14.5 mg/dl, P<0.01) than females with normal BMI and normal BFM. Conclusions: A considerable number of young Japanese women with a normal BMI have excess BFM and relatively higher lipid and leptin levels. These fndings may provide an important basis for future epidemiological surveys and studies.

Original languageEnglish
Pages (from-to)534-539
Number of pages6
JournalCirculation Journal
Issue number3
Publication statusPublished - Mar 1 2009
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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