Liposomes for tumor-targeted therapy

Akira Ito, Hiroyuki Honda, Takeshi Kobayashi

Research output: Contribution to journalArticlepeer-review

Abstract

Liposomes are the models of membranes. Liposomalization of various drugs has revealed the enhancement of their efficacy : Since liposomes can reduce the side effect of the drugs by the sitespecific delivery, intracellular targeting, and controlled release of drugs, many functional liposomes have been developed including cationic liposomes and antibody-conjugating im munoliposomes. In this article, the preparation and characterization of functional liposomes are discussed. We have developed intracellular hyperthermia using magnetic nanoparticles (magnet ites) by the feature that magnetites can generate heat under high frequency alternative magnetic field. In addition, magnetites affect the magnetic gradient in a magnetic field and those can be used as a contrast enhancement reagent for MRI. Therefore, if magnetite can be accumulated only in tumor tissue, they can afford cancer diagnosis and tumor-specific hyperthermia. To deliver the magnetites toward tumors, two kinds of functional liposomes have been developed, which were “gmagnetite cationic liposomes(IVICLs)” and “Fab '-conjugating magnetoliposomes (FMLs)”. MCLs were designed for the intratumor injection and showed the high affinity to the tumor cells. On the other hands, FMLs were designed for “missile liposomes” which can accumu late in the tumor by antigens-antibody reaction even in the case of intravascular injection. Here, we review these functional liposomes and discussed how to achieve the ultimate goal for umor targeting.

Original languageEnglish
Pages (from-to)347-354
Number of pages8
JournalDrug Delivery System
Volume17
Issue number4
DOIs
Publication statusPublished - Jan 1 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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