Liprin-α4 as a Possible New Therapeutic Target for Pancreatic Cancer

Akio Yamasaki, Kazunori Nakayama, Akira Imaizumi, Makoto Kawamoto, Akiko Fujimura, Yasuhiro Oyama, Shuntaro Nagai, Kosuke Yanai, Hideya Ohnishi

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Abstract

BACKGROUND/AIM: In pancreatic cancer, where the microenvironment is extremely hypoxic, analyzing signal transduction under hypoxia is thought to be significantly important. By investigating microarray analysis of pancreatic cancer cells cultured under both normoxia and hypoxia, we found that the expression of leukocyte common antigen-related (LAR)-interacting protein (liprin)-α4 was extremely increased under hypoxia compared to under normoxia.

MATERIALS AND METHODS: In the present study, the biological significance of liprin-α4 in pancreatic cancer was investigated and whether liprin-α4 has potential as a therapeutic target for pancreatic cancer was estimated.

RESULTS: Suppression of liprin-α4 reduced proliferation of pancreatic cancer cells both in vitro and in vivo. Inhibition of liprin-α4 also reduced invasiveness through the suppression of endothelial-mesenchymal transition. Stimulation by liprin-α4 was through phosphoinositide 3-kinase and mitogen-activated protein kinase signaling pathways.

CONCLUSION: Liprin-α4 plays a pivotal role in inducing malignant phenotypes such as increased proliferation and invasion in pancreatic cancer, and that liprin-α4 could be a new effective therapeutic target for pancreatic cancer.

Original languageEnglish
Pages (from-to)6649-6654
Number of pages6
JournalAnticancer research
Volume37
Issue number12
Publication statusPublished - Dec 1 2017

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Pancreatic Neoplasms
Proteins
Therapeutics
CD45 Antigens
1-Phosphatidylinositol 4-Kinase
Tumor Microenvironment
Microarray Analysis
Mitogen-Activated Protein Kinases
Cultured Cells
Signal Transduction
Phenotype
Hypoxia

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Yamasaki, A., Nakayama, K., Imaizumi, A., Kawamoto, M., Fujimura, A., Oyama, Y., ... Ohnishi, H. (2017). Liprin-α4 as a Possible New Therapeutic Target for Pancreatic Cancer. Anticancer research, 37(12), 6649-6654.

Liprin-α4 as a Possible New Therapeutic Target for Pancreatic Cancer. / Yamasaki, Akio; Nakayama, Kazunori; Imaizumi, Akira; Kawamoto, Makoto; Fujimura, Akiko; Oyama, Yasuhiro; Nagai, Shuntaro; Yanai, Kosuke; Ohnishi, Hideya.

In: Anticancer research, Vol. 37, No. 12, 01.12.2017, p. 6649-6654.

Research output: Contribution to journalArticle

Yamasaki, A, Nakayama, K, Imaizumi, A, Kawamoto, M, Fujimura, A, Oyama, Y, Nagai, S, Yanai, K & Ohnishi, H 2017, 'Liprin-α4 as a Possible New Therapeutic Target for Pancreatic Cancer', Anticancer research, vol. 37, no. 12, pp. 6649-6654.
Yamasaki A, Nakayama K, Imaizumi A, Kawamoto M, Fujimura A, Oyama Y et al. Liprin-α4 as a Possible New Therapeutic Target for Pancreatic Cancer. Anticancer research. 2017 Dec 1;37(12):6649-6654.
Yamasaki, Akio ; Nakayama, Kazunori ; Imaizumi, Akira ; Kawamoto, Makoto ; Fujimura, Akiko ; Oyama, Yasuhiro ; Nagai, Shuntaro ; Yanai, Kosuke ; Ohnishi, Hideya. / Liprin-α4 as a Possible New Therapeutic Target for Pancreatic Cancer. In: Anticancer research. 2017 ; Vol. 37, No. 12. pp. 6649-6654.
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